Girdin蛋白与乳腺癌相关性的研究进展

doi:10.11904/j.issn.1002-3070.2016.01.012

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (1): 57-60.doi: 10.11904/j.issn.1002-3070.2016.01.012

Girdin蛋白与乳腺癌相关性的研究进展

周婧, 综述, 李志高审校

哈尔滨医科大学附属肿瘤医院乳腺外科(哈尔滨 150081)

收稿日期:2015-10-26 出版日期:2016-02-28 发布日期:2016-02-25
通讯作者: 李志高,E-mail:drzhigaoli@126.com
作者简介:周婧,女,(1989-),硕士研究生,从事乳腺肿瘤的研究
基金资助:
黑龙江省自然科学基金项目(H201334)

Advances on correlation between Girdin protein and breast cancer

ZHOU Jing, LI Zhigao

Department of Breast Surgery,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2015-10-26 Online:2016-02-28 Published:2016-02-25

摘要/Abstract

摘要： Girdin蛋白是一种肌动蛋白结合蛋白,该蛋白具有复杂的分子结构并且参与多种与癌症发生相关的信号通路。这些生物学特性导致其与恶性肿瘤的增殖与侵袭紧密相关。近年来研究显示Girdin蛋白与乳腺癌的发生发展也有着密切的关系。Girdin蛋白在乳腺癌细胞中的表达,不仅能够促进乳腺癌的进展,还能够影响转移及预后。因此Girdin蛋白有望作为一个独立的生物学标志物,为乳腺癌治疗提供新的方向。

关键词: Girdin, 乳腺癌, 生物标志物

Abstract: Girdin protein is a kind of actin binding protein,which has the complex molecular structure and takes part in a variety of signaling pathways related with causing cancer.The biological characteristics of Girdin protein have close association with the proliferation and invasion of malignant tumor.Recent studies have shown that Girdin protein is closely related with occurrence and progress of breast cancer.Girdin protein expression in breast cancer cells can not only promote the progress of breast cancer,but also affect the lymph node metastasis and prognosis.Therefore Girdin protein is expected as an independent biomarker to provide a new direction for breast cancer treatment.

Key words: Girdin, Breast cancer, Biomarker

中图分类号:

R737.9

周婧, 综述, 李志高审校. Girdin蛋白与乳腺癌相关性的研究进展[J]. 实用肿瘤学杂志, 2016, 30(1): 57-60.

ZHOU Jing, LI Zhigao. Advances on correlation between Girdin protein and breast cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(1): 57-60.

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Girdin蛋白与乳腺癌相关性的研究进展

Advances on correlation between Girdin protein and breast cancer

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