宫颈癌持续或复发患者个体化化疗研究

doi:10.11904/j.issn.1002-3070.2016.03.009

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (3): 240-244.doi: 10.11904/j.issn.1002-3070.2016.03.009

宫颈癌持续或复发患者个体化化疗研究

胡月, 唐冬

华中科技大学同济医学院附属荆州医院肿瘤科(荆州 434020)

收稿日期:2016-02-22 出版日期:2016-06-20 发布日期:2016-07-01
通讯作者: 唐冬,E-mail:tjmutangdong@163.com
作者简介:胡月,女,(1987-),硕士,主治医师,从事妇科肿瘤的研究

Research of individual chemotherapy in patients with cervical cancer recurrence or continuous after radiation and chemotherapy

HU Yue,TANG Dong

Department of Oncology,Jingzhou Hospital,Tongji Medical College,Huazhong University of Science and Technology,Jingzhou 434020,China

Received:2016-02-22 Online:2016-06-20 Published:2016-07-01

摘要/Abstract

摘要： 目的比较个体化化疗与常规化疗在宫颈癌放化疗后持续、复发患者中的疗效。方法选取2013年1月—2015年12月于荆州市中心医院治疗的宫颈癌复发或持续患者60例并随机分为研究组和对照组。其中研究组(30例)根据基因检测结果制定个体化化疗方案,对照组(30例)采用吉西他滨联合顺铂方案化疗,2周期化疗后比较临床疗效以及不良反应发生率。结果研究组有效率(RR)、疾病控制率(DCR)均高于对照组(P＜0.05)。研究组中位无进展生存期为6.5个月,显著高于对照组2.9个月(P＜0.01)。骨髓抑制发生率明显低于对照组(P＜0.05),其他不良反应发生率无统计学差异(P＞0.05)。结论对于宫颈癌放化疗后持续、复发患者个体化化疗优于经验性化疗。

关键词: 宫颈癌, 个体化化疗, 肿瘤

Abstract: Objective To compare the curative effect of individual chemotherapy with routine chemotherapy in patients with cervical cancer recurrence or continuous after radiation and chemotherapy.Methods 60 patients with cervical cancer recurrence or continuous after radiation and chemotherapy,and hospitalized in JingZhou Center Hospital between January 2013 and December 2015 were selected.They were divided into experimental group and control group randomly.The individualized chemotherapy programs were made based on the results of genetic testing in experimental group(30 eases).Gemcitabine combined cisplatin chemotherapy were used in the control group(30 eases).Evaluated the clinical efficacy and toxicity the incidence of adverse reactions after 2 curative cycles.Results The RR and DCR were significantly higher in the research than in the control group(P＜0.05).Median progression-free survival of experimental group was 6.5 months,significantly higher than 2.9 months of control group(P＜0.01).Marrow suppression in control group was more serious than in experimental group(P＜0.05).And no significant difference was found between groups in other adverse reactions(P＞0.05).Conculsion Individual chemotherapy had a better clinical curative effect than routine chemotherapy in patients with cervical cancer recurrence or continuous after radiation and chemotherapy.

Key words: Cervical cancer, Individual chemotherapy, Tumor

中图分类号:

R737.33

胡月, 唐冬. 宫颈癌持续或复发患者个体化化疗研究[J]. 实用肿瘤学杂志, 2016, 30(3): 240-244.

HU Yue,TANG Dong. Research of individual chemotherapy in patients with cervical cancer recurrence or continuous after radiation and chemotherapy[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(3): 240-244.

参考文献

1 吕琳.宫颈癌早期筛查方法研究进展[J].实用肿瘤学杂志,2011,25(4):381-383.
2 吴云云,刘鹏飞.GSTP1、XRCC1基因多态性与结直肠癌个体化治疗的研究进展[J].医学综述,2014,20(18):3319-3321.
3 韩瑛,李淑敏.分子诊断技术在卵巢癌个体化诊治中应用的现状与进展[J].癌症进展,2015,13(1):14-18.
4 Jiang J,Liang X,Zhou X,et al.ERCC1 expression as a prognostic and predictive factor in patients with non-small cell lung cancer:a meta-analysis[J].Mol Biol Rep,2012,39(6):6933-6942.
5 Wu J,Lu LY,Yu X.The role of BRCA1 in DNA damage response[J].Protein Cell,2010,1(2):117-123.
6 付婷,秦立强,潘旭东,等.XRCC1基因多态性与晚期非小细胞肺癌铂类化疗敏感性关系的Meta分析[J].江苏医药,2015,41(12):1401-1403.
7 陈健,何义富,胡冰.核苷酸切除修复基因多态性和铂类药物耐药性关系研究进展[J].现代肿瘤医学,2009,17(4):763-766.
8 车彪,邵增务,杨述华.Stathmin基因表达与肿瘤的研究进展[J].现代肿瘤医学,2008,16(10):1814-1817.
9 Hsieh SY,Huang SF,Yu MC,et al.Stathmin1 overexpression associated with polyploidy,tumor-cell invasion,early recurrence,and poor prognosis in human hepatoma[J].Mol Carcinog,2010,49(5):476-487.
10 Jakobsen A,Nielsen JN,Gyldenkerne N,et al.Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity[J].J Clin Oncol,2005,23(7):1365-1369.
11 Ogura K.Dihydropyrimidine dehydrogenase activity and its genetic aberrations[J].Gan To Kagaku Ryoho,2006,33(8):1041-1048.
12 蔡乐,朱珠.二氢嘧啶脱氢酶及其与5-氟尿嘧啶疗效和毒性的关系[J].中国药学杂志,2007,42(19):1441-1445.
13 Vena F,Li CE,Rodriguez-Justo M,et al.The MEK1/2 inhibitor pimasertib enhances gemcitabine efficacy in pancreatic cancer models by altering ribonucleotide reductase subunit-1(RRM1)[J].Clin Cancer Res,2015,21(24):5563-5577.
14 Ulker M,Duman BB,Sahin B,et al.ERCC1 and RRM1 as a predictive parameter for non-small cell lung,ovarian or pancreas cancer treated with cisplatin and/or gemcitabine[J].Contemp Oncol(Pozn),2015,19(3):207-213.
15 张艳,赵军,凯塞尔·吾甫尔,等.新疆维吾尔族和哈萨克族健康人群CYP2C9和VKORC1基因多态性研究[J].中国药师,2013,16(12):1759-1763.

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宫颈癌持续或复发患者个体化化疗研究

Research of individual chemotherapy in patients with cervical cancer recurrence or continuous after radiation and chemotherapy

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