NQO1高表达提示宫颈癌预后不良

doi:10.11904/j.issn.1002-3070.2016.04.012

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (4): 351-355.doi: 10.11904/j.issn.1002-3070.2016.04.012

NQO1高表达提示宫颈癌预后不良

侯立春¹,林黎娟²

1.丹东市妇女儿童医院病理科(丹东 118000);
2.辽东学院医学院分子医学研究室

收稿日期:2016-04-14 出版日期:2016-08-10 发布日期:2016-08-19
通讯作者: 林黎娟,E-mail:linlijuan3066@163.com
作者简介:侯立春,男,(1971-),本科,副主任医师,从事临床病理学的研究

NQO1 overexpression is associated with poor prognosis in the uterine cervix carcinoma

HOU Lichun¹,LIN Lijuan²

1.Department of Pathology,Dandong Women′s & Children′s Hospital,Dandong 118000,China;
2.Molecular medicine research,Eastern Liaoning University

Received:2016-04-14 Online:2016-08-10 Published:2016-08-19

摘要/Abstract

摘要： 目的探讨NQO1蛋白在宫颈癌中的表达及其临床意义。方法免疫组化检测NQO1蛋白在123例宫颈癌标本的表达并比较其与临床病理学参数的相关性,Kaplan-Meier分析NQO1表达对患者无病生存期(DFS)和总生存期(OS)的影响,Cox分析宫颈癌的预后风险因素。结果 NQO1蛋白在宫颈癌中呈胞浆染色,其表达率明显高于正常宫颈组织,且NQO1高表达率与肿瘤组织分化、临床分期、淋巴结转移和HPV感染明显相关;NQO1高表达患者的DFS和OS均明显低于低表达者;NQO1高表达是宫颈癌患者预后不良的独立风险因素。结论 NQO1高表达可能是评估宫颈癌预后不良的生物学指标。

关键词: 宫颈癌, NQO1, HPV病毒, 生存分析

Abstract: Objective To investigate the clinicopathological significance of upregulated NQO1 protein expression in uterine cervix carcinoma(UCC).Methods Immunohistochemical staining was performed on paraffin-embedded UCC specimens from 123 patients.Disease-free survival(DFS)and overall survival(OS)rates for all cervical UCC patients were calculated using the Kaplan-Meier method,and univariate or multivariate analyses were performed using the Cox proportional hazards regression model.Results The NQO1 protein showed a mainly cytoplasmic staining pattern in cervical cancer cells,and the strongly positive rate of NQO1 was significantly higher in UCC.High-level NQO1 was closely associated with poor differentiation,late-stage,lymph node metastasis and high-risk for HPV infection.Additionally,high-level NQO1 was associated with lower DFS and OS rates.Furthermore,Cox analysis revealed that NQO1 expression emerged as a significant independent hazard factor for DFS rate in patients with UCC.Conclusion NQO1 overexpression might be an independent biomarker for prognostic evaluation of UCCs.

Key words: Uterine cervix carcinoma, NQO1, Human papillomavirus, Survival analysis

中图分类号:

R366

侯立春,林黎娟. NQO1高表达提示宫颈癌预后不良[J]. 实用肿瘤学杂志, 2016, 30(4): 351-355.

HOU Lichun ,LIN Lijuan. NQO1 overexpression is associated with poor prognosis in the uterine cervix carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(4): 351-355.

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NQO1高表达提示宫颈癌预后不良

NQO1 overexpression is associated with poor prognosis in the uterine cervix carcinoma

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