SALL4基因在人恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2016.05.019

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (5): 477-480.doi: 10.11904/j.issn.1002-3070.2016.05.019

• 综述 • 上一篇

SALL4基因在人恶性肿瘤中的研究进展

王珏综述, 张惠洁审校

内蒙古医科大学第三附属医院肿瘤内科(包头 014010)

收稿日期:2015-04-29 出版日期:2016-10-28 发布日期:2016-11-02
通讯作者: 张惠洁,E-mail:zhanghuijie1210@163.com
作者简介:王珏,女,(1988-),硕士研究生,从事肿瘤内科的研究

Research progress of SALL4 gene in malignant tumor disease

WANG Jue, ZHANG Huijie

Department of Oncology,The Third Affiliated Hospital of Inner Mongolia Medical College,Baotou 014010,China

Received:2015-04-29 Online:2016-10-28 Published:2016-11-02

摘要/Abstract

摘要： 恶性肿瘤是当今严重威胁人类健康的一类疾病,其发病机制复杂,由人体中各种致癌因子相互作用引起。人类婆罗双树样基因(SALL4)是一种新发现的基因,因具有C2H2锌指结构的蛋白转录因子,在胚胎干细胞功能方面起重要作用。研究发现,该基因突变常导致恶性肿瘤的发生。本文就SALL4在恶性肿瘤发生发展中的分子机制及其对恶性肿瘤的诊断与治疗的作用等方面进行综述。

关键词: 原癌基因, SALL4, 肿瘤

Abstract: Malignant tumor is a serious threat to human health and its pathogenesis is complex,which caused by interaction of a variety of carcinogenic factors in the human body.SALL4 gene is a kind of newly discovered gene and it plays an important role in function of embryonic stem cell due to its protein transcription factor with C2H2 zinc finger domain.Studies found that this gene mutation often Results in occurrence of malignant tumor.This paper will summarize the molecular mechanism of SALL4 in the occurrence and development of malignant tumor and its diagnosis and treatment on malignant tumor.

Key words: Proto-oncogene, SALL4, Tumor

中图分类号:

R73.37

王珏综述, 张惠洁审校. SALL4基因在人恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2016, 30(5): 477-480.

WANG Jue, ZHANG Huijie. Research progress of SALL4 gene in malignant tumor disease[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 477-480.

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SALL4基因在人恶性肿瘤中的研究进展

Research progress of SALL4 gene in malignant tumor disease

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