纳米材料在肿瘤光动力治疗中的应用

doi:10.11904/j.issn.1002-3070.2018.03.011

摘要/Abstract

摘要： 光动力治疗(Photodynamic therapy,PDT)是利用光动力学反应,即在分子氧存在的情况下通过特定波长的光照射激活光敏剂,产生包括单线态氧的活性氧物质杀伤肿瘤细胞的一种治疗手段。光动力治疗肿瘤具有创伤小、选择性强、低毒性、适用性好的优点,但是,缺乏理想的光敏剂(Photosensitizer,PS),光源组织穿透深度不足,以及肿瘤组织缺氧等问题已经严重限制了光动力治疗在临床上的应用。纳米材料可解决光动力治疗中遇到的上述问题,因此近来在肿瘤光动力治疗中得以广泛应用,本综述将对纳米颗粒在光动力治疗中的应用进展进行综述。

关键词: 恶性肿瘤, 光动力治疗, 纳米材料

Abstract: Photodynamic therapy(PDT)utilizes a photodynamic reaction,that is,a photosensitizer(PSs)activated by light of a specific wavelength in the presence of molecular oxygen to produce a reactive oxygen species including singlet oxygen to kill tumor cells.PDT has the advantages of less trauma,high selectivity,low toxicity,and good applicability.However,the lack of an ideal PS,lack of light source tissue penetration depth,and hypoxia of tumor tissue have been severely restricted in clinical practice.Nanomaterials can solve the above problems encountered in photodynamic therapy,and have recently been widely used in PDT of tumor.Thus,this review will summarize the application progress of nanoparticles in PDT.

Key words: Malignant tumors, Photodynamic therapy, Nanoparticles

中图分类号:

R730.5

周洁, 陈钰(综述), 陈道桢(审校). 纳米材料在肿瘤光动力治疗中的应用[J]. 实用肿瘤学杂志, 2018, 32(3): 245-249.

ZHOU Jie, CHEN Yu, CHEN Daozhen. Application of nanoparticles in photodynamic therapy of tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 245-249.

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