代谢可塑性在肿瘤生长与转移中的研究进展

doi:10.11904/j.issn.1002-3070.2018.04.016

摘要/Abstract

摘要： 癌细胞必须改变代谢活动以满足其快速生长、转移及生物合成所需要的能量,肿瘤转移的不同阶段也需要扩散的癌细胞做出适当的代谢调整。本文将对原发肿瘤的代谢异质性进行阐述,同时总结了原发肿瘤细胞在转移过程中代谢策略的变化,并讨论了癌细胞在定植到不同微环境时发生的代谢改变以及其影响转移部位间质细胞代谢的机制。通过这些讨论,我们认识到肿瘤代谢的可塑性使癌细胞适应不利的环境,因此针对肿瘤代谢的治疗将有望成为一种改变肿瘤转移预后的治疗手段。

关键词: 肿瘤, 转移, 代谢

Abstract: Cancer cells must change their metabolic activity to meet the energy needed for their rapid growth,metastasis,and biosynthesis.Different stages of tumor metastasis require the proliferation of cancer cells to make appropriate metabolic adjustments.This review summarizes primary tumor metabolism heterogeneity.At the same time,we summarize the changes in the metabolic strategies of primary tumor cells during metastasis and discuss metabolic changes of cancer that occur when cancer cells are colonized into different microenvironments as well as their mechanisms by which cells affect the metabolism of metastatic cells in metastatic sites.Through these discussions,we have clearly realized that the plasticity of tumor metabolism allows cancer cells to adapt and grow in unfavorable environments.The treatment of tumor metabolism is expected to become a treatment method to change the prognosis of tumor metastasis.

Key words: Tumor, Metastatic, Metabolism

中图分类号:

张译匀, 吴华星. 代谢可塑性在肿瘤生长与转移中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(4): 362-366.

ZHANG Yiyun,WU Huaxing. Progress of metabolic plasticity in tumor growth and metastasis[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(4): 362-366.

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