伏核微量注射异丁司特对吗啡成瘾大鼠甩尾痛阈的影响

doi:10.11904/j.issn.1002-3070.2019.03.004

实用肿瘤学杂志 ›› 2019, Vol. 33 ›› Issue (3): 211-214.doi: 10.11904/j.issn.1002-3070.2019.03.004

伏核微量注射异丁司特对吗啡成瘾大鼠甩尾痛阈的影响

徐秋菊¹,张广文²

1.哈尔滨医科大学附属肿瘤医院(哈尔滨 150081);
2.浙江省台州市第一人民医院

收稿日期:2018-11-19 修回日期:2019-01-14 出版日期:2019-06-20 发布日期:2019-06-18
通讯作者: 张广文,E-mail:guangwenzhang@126.com
作者简介:徐秋菊,女,(1977-),本科,技师,从事肿瘤病理学的研究
基金资助:
黑龙江省卫生厅科研课题(编号:2011-133)

Effect of ibudilast-microinjected into nucleus accumbens on appendix pain threshold in morphine-addicted rats

XU Qiuju¹,ZHANG Guangwen²

1.Harbin Medical University Cancer Hospital,Harbin 150081,China;
2.The First People′s Hospital of Taizhou

Received:2018-11-19 Revised:2019-01-14 Online:2019-06-20 Published:2019-06-18

摘要/Abstract

摘要： 目的研究伏核(Nucleus accumbens NAC)内微量注入异丁司特对吗啡成瘾大鼠甩尾痛阈的影响。方法正常大鼠及吗啡成瘾大鼠伏核经玻璃微电极注入异丁司特(5 μg/2 μL)或生理盐水(2 μL)后,以甩尾潜伏期(TFL)为指标,观察注药前后的镇痛作用。结果正常大鼠及吗啡成瘾大鼠伏核内注入5 μg的异丁司特后,与注药前相比,其TFL延长,并且吗啡成瘾大鼠TFL延长较正常大鼠更为显著;Wistar正常大鼠及吗啡成瘾大鼠伏核注入2 μL生理盐水后,TFL无显著变化。结论大鼠及吗啡成瘾大鼠伏核内微量注入异丁司特后,可使其产生镇痛作用,并且吗啡成瘾大鼠的镇痛效果更为显著。

关键词: 伏核, 异丁司特, 吗啡成瘾, 甩尾潜伏期

Abstract: Objective The aim of this study was to investigate the effect of microinjection ibudilast on the appendix pain threshold in nucleus accumbens(NAC)of morphine-addicted rats.Methods Normal rats and morphine-addicted rats were injected with ibudilast(5 μg/2 μL)or saline(2 μL)into NAC through glass microelectrode.The tail-flick period(TFL)was used as an indicator to observe the thermal pain threshold before and after ibuilast injection.Results After injected ibudilast 5 μg into the NAC of normal rats and morphine-added rats,the TFL was prolonged compared with that before injection,and the TFL prolongation of morphine-addicted rats was more significant than that of normal rats.There was no significant change in TFL after 2 μL of saline was injected into the NAC of normal rats and morphine-addicted rats.Conclusion Microinjection of ibudilast into NAC of normal rats and morphine-added rats can cause analgesic effect,and the analgesic effect of morphine-addicted rats is more significant.

Key words: Nucleus accumbens, Ibudilast, Morphine-addicted, Tail-flick latency

中图分类号:

徐秋菊,张广文. 伏核微量注射异丁司特对吗啡成瘾大鼠甩尾痛阈的影响[J]. 实用肿瘤学杂志, 2019, 33(3): 211-214.

XU Qiuju,ZHANG Guangwen. Effect of ibudilast-microinjected into nucleus accumbens on appendix pain threshold in morphine-addicted rats[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 211-214.

参考文献 1

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伏核微量注射异丁司特对吗啡成瘾大鼠甩尾痛阈的影响

Effect of ibudilast-microinjected into nucleus accumbens on appendix pain threshold in morphine-addicted rats

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