NKT细胞对肝癌免疫应答的双向调控作用

doi:10.11904/j.issn.1002-3070.2019.06.012

摘要/Abstract

摘要： 自然杀伤T(Natural killer T,NKT)细胞是一种特殊的T淋巴细胞亚群,也是肝脏内的天然免疫淋巴细胞,可分泌大量的细胞因子参与肝癌免疫调节,在肝癌的发生、发展和转移等免疫应答中发挥双重调控作用。其促肿瘤和抗肿瘤的双重调节功能与多种因素相关,本文对近年来NKT细胞对肝癌免疫的双向调控作用机制的研究进展进行总结。

关键词: NKT细胞, 肝癌, 免疫应答, 双向调控, 研究进展

Abstract: Natural killer T(NKT)cells are a special T lymphocytes subset,which is also natural immune lymphocytes in the liver.It can secrete a large number of cytokines involved in the immune regulation of liver cancer and play dual regulatory roles in the immune response such as the occurrence,development and metastasis of liver cancer.The dual regulation function of promoting tumor and anti-tumor is related to various factors.This paper summarizes the research progress of the two-way regulation mechanism of NKT cells on liver cancer immunity in recent years.

Key words: NKT cells, Liver cancer, Immune response, Bidirectional regulation, Research progress

中图分类号:

R735.7

李素素, 周春祥. NKT细胞对肝癌免疫应答的双向调控作用[J]. 实用肿瘤学杂志, 2019, 33(6): 540-543.

LI Susu, ZHOU Chunxiang. Two-way regulation of NKT cells on immune response to liver cancer[J]. Journal of Practical Oncology, 2019, 33(6): 540-543.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2019.06.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2019/V33/I6/540

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