恶性肿瘤来源外泌体在巨噬细胞M2极化中作用的研究进展

doi:10.11904/j.issn.1002-3070.2022.01.011

实用肿瘤学杂志 ›› 2022, Vol. 36 ›› Issue (1): 59-63.doi: 10.11904/j.issn.1002-3070.2022.01.011

恶性肿瘤来源外泌体在巨噬细胞M2极化中作用的研究进展

史竞彤, 陈敏捷综述, 孙轶华审校

哈尔滨医科大学附属肿瘤医院检验科(哈尔滨 150081)

收稿日期:2021-03-07 修回日期:2021-04-07 出版日期:2022-02-28 发布日期:2022-01-21
通讯作者: 孙轶华,E-mail:syh200415@126.com
作者简介:史竞彤,女,(1994-),硕士研究生,从事临床检验诊断学方面的研究。
基金资助:
国家自然科学基金(编号:81772253)

Research progress in the role of malignant tumor-derived exosomes in the M2 polarization of macrophages

SHI Jingtong, CHEN Minjie, SUN Yihua

Department of Clinical Laboratory,Harbin Medical University Cancer Hospital,Harbin 150081,China

Received:2021-03-07 Revised:2021-04-07 Online:2022-02-28 Published:2022-01-21

摘要/Abstract

摘要： 外泌体是纳米(30~150 nm)膜结合囊泡,内部包含多种生物活性物质,如脂质、蛋白质、mRNA以及非编码RNA等,在正常和病理条件下几乎所有细胞都可以分泌。研究发现肿瘤细胞可通过分泌外泌体将核酸、蛋白质等生物活性分子传递给受体细胞,改变受体细胞的表型或功能,进一步改变肿瘤微环境而影响肿瘤的进展。本文根据研究进展对肿瘤细胞外泌体在改变巨噬细胞表型方面所发挥的作用进行简要的介绍。

关键词: 外泌体, M2型巨噬细胞, 肿瘤

Abstract: Exosomes are nanometer(30~150 nm)membrane-bound vesicles,which contain a variety of bioactive substances,such as lipids,proteins,mRNA,and non-coding RNA,which can be secreted by almost all cells under normal and pathological conditions.Many studies have found that tumor cells can deliver bioactive molecules such as nucleic acid and proteins to recipient cells by secreting exosomes,changing the phenotype or function of recipient cells,and further changing the tumor microenvironment to affect tumor progression.Based on the research progress,this article briefly introduces the role of tumor exosomes in changing the phenotype of macrophage.

Key words: Exosome, M2 type macrophages, Tumor

中图分类号:

R730.2

史竞彤, 陈敏捷, 孙轶华. 恶性肿瘤来源外泌体在巨噬细胞M2极化中作用的研究进展[J]. 实用肿瘤学杂志, 2022, 36(1): 59-63.

SHI Jingtong, CHEN Minjie, SUN Yihua. Research progress in the role of malignant tumor-derived exosomes in the M2 polarization of macrophages[J]. Journal of Practical Oncology, 2022, 36(1): 59-63.

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恶性肿瘤来源外泌体在巨噬细胞M2极化中作用的研究进展

Research progress in the role of malignant tumor-derived exosomes in the M2 polarization of macrophages

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