Abstract: Image guided stereotactic body radiation therapy(SBRT)has emerged as a promising technology for early-stage non-small cell lung cancer(NSCLC)increasingly,particularly for patients that are unable to tolerate or deny operation,with a trend to replace surgical resection.Abundant clinical research results have demonstrated that SBRT is safe to yield local control rate of more than 90% without excessive toxicity in early-stage NSCLC.In this review,we discuss the research progress on treating stage I NSCLC with SBRT.