Abstract: Objective To investigate the correlation between TIP30 and VEGF-C expression and clinicophathological characteristics in resected small cell lung cancer(SCLC)patients and to identify patients with increased risk of cancer recurrence and to provide a theoretical basis for the further clinical prevention of SCLC.Methods Sixty eight resected SCLC patients were included in this study.Paraffin-embedded specimens of patients were used for the evaluation of TIP30 and VEGF-C expression by immunohistochemistry.Results The expression of VEGF-C had positive correlation with lymph node metastasis.TIP30 expression was positively correlated with VEGF-C expression.Patients with low TIP30 expression had shorter Overall survival(OS)and Disease-Free survival(DFS)than those with high TIP30 expression.OS and DFS of the patients with VEGF-C-positive tumors were significantly lower than that of the patients with VEGF-C negative tumors.The multivariate Cox regression analysis showed that low TIP30 and high VEGF-C expression were independent markers of poor OS(P＜0.01)in operable SCLC patients.Conclusion The expression of VEGF-C shows positive correlation with lymph node metastasis.Low TIP30 and high VEGF-C expression are independent prognostic markers of poor overall survival in resected SCLC patients.