Abstract: Thoracic radiotherapy is an important means of local treatment for non-small cell lung cancer(NSCLC).Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)have the effect of systemic therapy.Studies have shown that NSCLC patients with EGFR exons 19,21 mutation have a synergistic effect in the combination therapy.Radiotherapy activates EGFR signaling pathway,inducing cell proliferation and DNA damage repair,leading to radiation resistance.Therefore,EGFR-TKIs have the effect in increasing radiosensitivity.Lung injury is one of the most common side effects when the two therapies combined.Studies suggest that radiotherapy combined with EGFR-TKIs may have conflicting functions in the development of pulmonary fibrosis,the discrepancy between these studies may depend on the differences in the experimental systems,the differences in pulmonary fibrosis models,as well as the differences between different species and individuals.Therefore,a more complete understanding of the etiology for pulmonary fibrosis is necessary to the development of improved treatments.