PRACTICAL ONCOLOGY JOURNAL ›› 2015, Vol. 29 ›› Issue (2): 178-182.doi: 10.11904/j.issn.1002-3070.2015.02.018

• Review • Previous Articles     Next Articles

Research progress of Hedgehog-Gli signaling pathway in lung cancer

WANG Lei,CHEN Gongyan   

  1. Department of Oncology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China
  • Received:2014-09-17 Online:2015-04-28 Published:2015-05-05

Abstract: Hedgehog-Gli signaling pathway involves in vertebrate embryonic development,tissue differentiation,organogenesis,and plays an important role in homeostasis,the maintenance of stem cell function,regulation of epithelial mesenchymal transition.Hedgehog-Gli signaling pathway activation correlates with a variety of tumor development,invasion,apoptosis and drug resistance.This review seeks to clarify the composition of Hedgehog-Gli signaling pathway,mechanism of action,the role of Hedgehog-Gli signaling pathway in lung cancer development and function of lung cell of the EGFR-TKI resistance.

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