Abstract: Objective To improve the clinical diagnosis and prognosis of the treatment of primary liver carcinoma with bone metastasis.Methods A retrospective study on diagnosis and treatment of bone metastasis from 55 cases of primary liver carcinoma was developed.Survival rates were calculated by Kaplan-meier method,univariates analysed by Log-rank and multivariates analysed by Cox regression.Results The 1-,2-and 3-year cumulative survival rates of the cases from primary liver carcinoma were 54.5%,25.5% and 16.4% respectively.The mediate survival time was 13 months.And the cases with bone metastasis were 23.6%,10.9% and 1.8% respectively.The mediate survival time was 5.5 months.Factors such as metastasis to other organs,liver function,and the combined modality therapy were independent prognostic factors.While number of bone metastasis,AFP level and number of liver cancer had no significant relations with the survival rate.Conclusion The prognosis of bone metastasis from primary liver carcinoma is poor.It is important to take emphasis on combined modality therapy,which may be benefit on reducing the symptom,improving the quality and prolong the life span.

Key words: Primary liver carcinoma, Bone metastasis, Diagnosis, Treatment