男乳癌与AR基因CAG重复多态性的相关性研究

doi:10.11904/j.issn.1002-3070.2015.06.003

PRACTICAL ONCOLOGY JOURNAL ›› 2015, Vol. 29 ›› Issue (6): 492-496.doi: 10.11904/j.issn.1002-3070.2015.06.003

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Related research of male breast cancer and CAG repeat polymorphism of AR gene

CUI Jialin¹, HUANG Rui², JIANG Yongdong³, HAN Jiguang³, NIU Ming³, WEI Wei³, ZHENG Wei³, SONG Yanni³

1.Clinical Laboratory,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China;
2.Department of Surgery,The Second Affiliated Hospital of Harbin Medical University;
3.Department of Breast Surgery,The Affiliated Tumor Hospital of Harbin Medical University

Received:2015-07-08 Online:2015-12-28 Published:2015-12-28

Abstract

Abstract: Objective To investigate the correlation between(CAG)n repeat polymorphism of androgen receptor(AR)gene and male breast cancer.Methods 40 cases of male breast cancer and 40 controls were collected.DNA was extracted from peripheral blood and the AR gene CAG coding exon sequences for PCR amplification,sequencing and calculated the number of CAG repeats frquency.χ² test and Logistic regression analysis were used assess the AR gene CAG repeat length frequency affect the number of male breast cancer risk.Results There was statistically significant difference in male breast cancer cases and controls the number of CAG repeat length frequency.Man for whom the(CAG)n≥22 repeat sequence had 3.52 times risk of male breast compared(CAG)n≤22(OR=3.52,P=0.036).Conclusion AR gene CAG repeat length is a predictor of the frequency of male breast cancer risk.Longer CAG repeats can increase the risk of male breast cancer.

Key words: Male breast cancer, Androgen receptor, CAG repeat sequence, Polymorphic

CLC Number:

CUI Jialin, HUANG Rui, JIANG Yongdong, HAN Jiguang, NIU Ming, WEI Wei, ZHENG Wei, SONG Yanni. Related research of male breast cancer and CAG repeat polymorphism of AR gene[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(6): 492-496.

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Related research of male breast cancer and CAG repeat polymorphism of AR gene

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