三阴性乳腺癌中miRNA-124表达与E-钙黏蛋白及雄激素受体的关系

doi:10.11904/j.issn.1002-3070.2017.02.001

Abstract

Abstract: Objective The objective of this study was to explore the expression of miRNA-124(miR-124)and its correlation with E-cadherin and androgen receptor(AR)in triple-negative breast cancer(TNBC).Methods The expression of miR-124 was detected by RT-PCR in TNBC tissues and adjacent normal breast tissues.The expression of E-cadherin and AR in TNBC was detected by immunohistochemistry.Results The expression of miR-124 in TNBC tissues was significantly correlated with histological grade and the expression of E-cadherin(P＜0.05),and the expression of miR-124 in TNBC tissues was significantly lower than that in adjacent normal breast tissues.No correlation was found between miR-124 and AR in TNBC tissues(P＞0.05).Conclusion In TNBC,miR-124 may play an anti-tumor effect by modulating the expression of E-cadherin.

Key words: Triple-negative breast cancer, miR-124, E-cadherin, Androgen receptor

CLC Number:

R37.9

TANG Dabei,JIN Yan,GONG Zhenqin,CHU Zhong,CAO Zhongru,ZHANG Qingyuan. Expression of miR-124 and its relationship with E-cadherin and androgen receptor in triple-negative breast cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(2): 97-101.

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Expression of miR-124 and its relationship with E-cadherin and androgen receptor in triple-negative breast cancer

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