Abstract: Objective To study the expression of integrin-linked kinase(ILK) and E-cadherin in cervical intraepithelial neoplasia(CIN)and cervical squamous cell carcinoma,and analyze their relation with clinical pathological data.Methods Immunohistochemistry was used to detect the expression of ILK and E-cadherin in 54 cases of CIN,38 cases of cervical squamous cell carcinoma and 20 cases of normal cervical tissue.Results The positive expression rate of ILK in normal cervical,CINⅠ,CINⅡ~Ⅲ and cervical squamous cell carcinoma was 25.0%,68.8%,78.9% and 97.3%,respectively.The positive rate of ILK in CIN and cervical squamous cell carcinoma was significantly higher than that in normal cervix(P＜0.05).The positive expression rate of E-cadherin in the normal cervix,CINⅠ,CINⅡ~Ⅲ and cervical squamous cell carcinoma was 100.0%,75.0%,55.3% and 36.8%,respectively.The positive rate of E-cadherin in CIN and cervical squamous cell carcinoma was significantly lower than that in normal cervix(P＜0.05).There was a significant negative correlation of the expression of ILK and E-cadherin in cervical squamous cell carcinoma(r=-0.531,P＜0.01).The positive expression of E-cadherin had correlation with clinical stage,differentiation and lymph node metastasis in cervical squamous cell carcinoma(P＜0.05).Conclusion ILK and E-cadherin could be used as a marker to distinguish normal cervix from CIN and cervical squamous cell carcinoma.In addition,E-cadherin is also correlated with the malignant biological behavior of cervical cancer.