Journal of Practical Oncology ›› 2021, Vol. 35 ›› Issue (5): 426-430.doi: 10.11904/j.issn.1002-3070.2021.05.007

• Clinical Application • Previous Articles     Next Articles

Clinical effect of cervical cold knife conization combined with anti-HPV bioprotein dressing on HSIL treatment complicated with high-risk HPV infection

MA Li1, GUO Sihong2, ZHU Boyi1, CHEN Jie1   

  1. 1. Harbin Medical University Cancer Hospital,Harbin 150081,China;
    2. Heilongjiang University of Chinese Medicine
  • Received:2021-03-11 Revised:2021-05-06 Online:2021-10-28 Published:2021-10-25

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Abstract: Objective The aim of this study was to investigate the clinical effect and application value of cold knife conization combined with anti-HPV bioprotein dressing in the treatment of high-grade squamous intraepithelial lesion(HSIL)complicated with high-risk HPV infection. Methods A total of 220 patients received by the Harbin Medical University Cancer Hospital from September 2017 to December 2019 diagnosed with high-risk HPV infection and pathologically confirmed to be cervical intraepithelial neoplasia(CIN)grade Ⅱ~Ⅲ were randomly divided into observation group and control group.The control group was treated with CKC alone,and the observation group was treated with CKC combined with anti-HPV bioprotein dressings.After that,HPV,TCT and vaginal secretion were reviewed regularly,and the curative effects on the two groups were compared and evaluated. Results In the observation group,the negative rate of HPV in 6 months,9 months and 12 months after surgery were 51.82%,70.00% and 83.64%,respectively,and the total effective rates of treatment were 62.73%,82.73% and 91.82%,respectively,which were higher than those in the control group(P＜0.05).The abnormal rate of TCT in the observation group at 6 months and 12 months after surgery was lower than that in the control group(P＜0.05).There was no significant difference in the total effective rate for patients younger than 50 years old between the observation group and the control group(P＞0.05).The total effective rate of treatment for patients ≥50 years old in the observation group was better than that of the control group(P＜0.05).The normal rates of vaginal secretion in the observation group at 3 months,6 months,9 months and 12 months after surgery were 48.18%,64.55%,84.55%,92.73%,respectively,which were higher than those of the control group(P＜0.05). Conclusion The cervical cold knife conization combined with anti-HPV bioprotein dressing has a significant clinical effect in the treatment of HSIL combined with high-risk HPV infection.It can improve the vaginal environment,effectively promote the regression of high-risk HPV infection,reduce the risk of postoperative recurrence,and has more benefit for elderly women.

Key words: Human papilloma virus, High-grade squamous intraepithelial lesion of the cervix, Cold knife conization, Anti-HPV biological protein dressing

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