SALL4高表达在食管鳞癌临床病理及预后判定中的意义

doi:10.11904/j.issn.1002-3070.2021.05.006

Abstract

Abstract: Objective The aims of this study were to analyze the relationship between the expression of SALL4 in esophageal squamous cell carcinoma(ESCC)and clinicopathology and survival prognosis,and to explore the role of SALL4 in the diagnosis and treatment of esophageal squamous cell carcinoma. Methods Ninety patients with ESCC were treated in Harbin Medical University Cancer Hospital from July 2010 to November 2011.The expression of SALL4 was detected in ESCC and adjacent tissues by immunohistochemistry.Its relationship with clinical characteristics of patients with ESCC,overall survival(OS)and progression free survival(PFS)were analyzed. Results The expression of SALL4 in ESCC tissues was significantly higher than that in adjacent tissues.The high expression of SALL4 was closely related to intraoperative tumor site(P=0.038),G grade(P=0.036)and AJCC stage(P=0.015).Survival analysis and Cox risk regression analysis both showed that the OS and PFS of ESCC patients in the high expression of SALL4 group were lower than those in the low expression of SALL4 group. Conclusion The high expression of SALL4 can be used as an independent prognostic factor for ESCC.In clinical work,it can help judge the survival prognosis of patients with ESCC.

Key words: Esophageal squamous cell carcinoma, SALL4, Expressional analysis, Immunohistochemistry, Prognosis biomarkers

CLC Number:

R735.1

LU Junrong, WANG Huiwen, HE Dongfeng. Significance of high expression of SALL4 in clinicopathological and prognostic judgment of esophageal squamous cell carcinoma[J]. Journal of Practical Oncology, 2021, 35(5): 420-425.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.05.006

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I5/420

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Significance of high expression of SALL4 in clinicopathological and prognostic judgment of esophageal squamous cell carcinoma

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