RIZ1蛋白表达与宫颈鳞状细胞癌临床病理参数及放疗敏感性的相关性研究

doi:10.11904/j.issn.1002-3070.2017.05.004

Abstract

Abstract: Objective The aim of this study was to analyze the expression of RIZ1 and its association with clinicopathological factors or radiosensitivity in cervical squamous cell carcinoma.Methods 159 samples from patients with FIGO stage Ⅱ b and Ⅲ a cervical squamous cell carcinoma were collected and preserved before radiotherapy.The expression of RIZ1 in cervical squamous cell carcinoma tissues and 20 normal cervical tissues was assessed by immunohistochemistry.The relationship between the RIZ1 expression and the clinicopathological factors or radiosensitivity in cervical squamous cell carcinoma was analyzed by statistical analysis.Results The expression of RIZ1 protein was down-regulated in patients with cervical cancer(P＜0.001).The level of RIZ1 protein expression was close related to radiosensitivity(P=0.012),FIGO staging(P=0.004),deep myometrial invasion(P=0.026),and pelvic lymph node metastasis(P=0.005).Logistic regression analysis showed that the high expression of RIZ1 protein was an independent predictor of radiosensitivity in cervical cancer(P=0.045).Conclusion RIZ1 may be involved in the occurrence and development process of cervical squamous cell carcinoma and regard as a candidate biomarker for the sensitivity in cervical squamous cell carcinoma in radiotherapy.

Key words: Cervical cancer, RIZ1, Immunohistochemistry, Radiosensitivity

CLC Number:

R735.7

ZHANG Yunyan, LIU Yaqin, WANG Lei, ZHANG Lin, CHENG Haiyan, YANG Shanshan. Relationship between expression of RIZ1 and clinicopathological factors or radiosensitivity in human cervical squamous cell carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(5): 405-410.

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Relationship between expression of RIZ1 and clinicopathological factors or radiosensitivity in human cervical squamous cell carcinoma

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