PD-L1与MTA1在口腔鳞癌中的表达与临床意义

doi:10.11904/j.issn.1002-3070.2020.03.006

Abstract

Abstract: Objective The aims of this study were to investigate the expressions of programmed death-ligand1(PD-L1)and metastasis associated gene 1(MTA1)in oral squamous cell carcinoma and normal oral mucosa tissues as well as their correlation and clinical significance of clinical pathology parameters.Methods The immunohistochemical method was used to detect the expression of PD-L1 and MTA1 in 45 cases of oral squamous cell carcinoma tissues and 20 cases of normal oral mucosa tissues,and to analyze the correlation between their clinical pathological parameters and the expression of PD-L1 and MTA1.Results The positive rates of PD-L1 in oral squamous cell carcinoma and normal oral mucosa tissues were 75.56% and 15%,respectively.The positive rates of MTA1 in oral squamous cell carcinoma and normal oral mucosa tissues were 66.67% and 10%,respectively.The differences were statistically significant(P＜0.05).The expression of PD-L1 and MTA1 was related to the TNM stage of oral squamous cell carcinoma(P＜0.05),and the expression of PD-L1 and MTA1 in oral squamous cell carcinoma tissues was correlated(r=0.34,P＜0.01).Conclusion PD-L1 and MTA1 may play an important role in the development of oral squamous cell carcinoma,and may become a potential new joint target.

Key words: Oral squamous cell carcinoma, PD-L1, MTA1, Immunohistochemistry

CLC Number:

R739.8

ZHANG Lianqi,LI Jichen,PIAO Songlin,SAI Yin wuliji,YUAN Dongmei,SHEN Yuchen. Expression and clinical significance of PD-L1 and MTA1 in the oral squamous cell carcinoma[J]. Journal of Practical Oncology, 2020, 34(3): 220-224.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2020.03.006

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2020/V34/I3/220

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Expression and clinical significance of PD-L1 and MTA1 in the oral squamous cell carcinoma

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