HLA-G在乳腺癌中的表达及意义

doi:10.11904/j.issn.1002-3070.2018.05.005

Abstract

Abstract: Objective The Objective of this study was to investigate the expression of human leukocye antigen-G(HLA-G)in breast cancer patients and its role in the diagnosis and prognosis of breast cancer.Methods HLA-G protein was isolated and purified,and hybridoma cell lines secreting anti-HLA-G monoclonal antibody were screened to obtain anti-HLA-G monoclonal antibody.The expression of HLA-G in 235 primary breast cancer tissues was detected by immunohistochemistry.The relationship amongst HLA-G expression with various clinicopathological parameters,host immune response & survival rate was analyzed.Results The expression rate of HLA-G in breast cancer patients was 66%(155/235).The expression of HLA-G was related to tumor size,clinical TNM stage and lymph node metastasis.The survival rate of HLA-G negative patients was significantly higher than that of HLA-G positive patients.Conclusion HLA-G is highly expressed in breast cancer tissues.The expression of HLA-G is related to host immune response and prognosis of breast cancer.HLA-G is an independent factor affecting the prognosis of breast cancer patients.

Key words: Human leukocyte antigen-G(HLA-G), Breast cancer, Immunohistochemistry

CLC Number:

R737.9

HE Xu, YE shangmian, DONG dandan, LI Ke. The expression of HLA-G in breast cancer and its significance[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 410-414.

References

1 De Angelis C,Di Maio M,Crispo A,et al.Luminal-like HER2-negative stage IA breast cancer:a multicenter retrospective study on long-term outcome with propensity score analysis[J].Oncotarget,2017,8(68):112816-112824.
2 Generali D,Corona SP,Pusztai L,et al.Benefit of the addition of hormone therapy to neoadjuvant anthracycline-based chemotherapy for breast cancer:comparison of predicted and observed pCR[J].J Cancer Res Clin Oncol,2018,144(3):601-606.
3 Kaminski V,Ellwanger JH.Down-regulation of HLA-G gene expression as an immunogenetic contraceptive therapy[J].Med Hypotheses,2017,102:146-149.
4 Kapasi K,Albert SE,Yie S,et al.HLA-G has a concentration-dependent effect on the generation of an allo-CTL response[J].Immunology,2000,101(2):191-200.
5 Gregori S.HLA-G-mediated immune tolerance:past and new outlooks[J].Front Immunol,2016,7:653.
6 Johansen LL,Lock-Andersen J,Hviid TV.The pathophysiological impact of HLA class Ia and HLA-G expression and regulatory T cells in malignant melanoma:a review[J].J Immunol Res,2016,2016:6829283.
7 Alegre E,Rizzo R,Bortolotti D,et al.Some basic aspects of HLA-G biology[J].J Immunol Res,2014,2014(1):657625.
8 Sideras K,Biermann K,Yap K,et al.Tumor cell expression of immune inhibitory molecules and tumor-infiltrating lymphocyte count predict cancer-specific survival in pancreatic and ampullary cancer[J].Int J Cancer,2017,141(3):572-582.
9 Kailayangiri S,Altvater B,Spurny C,et al.Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G[J].Oncoimmunology,2017,6(9):e1250050.
10 Zhang RL,Zhang X,Dong SS,et al.Predictive value of different proportion of lesion HLA-G expression in colorectal cancer[J].Oncotarget,2017,8(64):107441-107451.
11 Wan R,Wang ZW,Li H,et al.Human leukocyte antigen-G inhibits the anti-tumor effect of natural killer cells via immunoglobulin-like transcript 2 in gastric cancer[J].Cell Physiol Biochem,2017,44(5):1828-1841.
12 Rodríguez JA.HLA-mediated tumor escape mechanisms that may impair immunotherapy clinical outcomes via T-cell activation[J].Oncology Letters,2017,14(4):4415-4427.
13 Spurny C,Kailayangiri S,Altvater B,et al.T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G[J].Oncotarget,2018,9(5):6536-6549.

[1]	WANG Xiaoya,XIAO Bin,LIAO Yang,TANG Rongzhi,SUN Zhaohui,LI Linhai. Expression of CXCR family proteins in different subtypes of breast cancer and their clinical prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 206-210.
[2]	LI Shuo,ZHANG Nannan,LI Liangliang,LONG Zhiping,YIN Huihui,ZHAO Yashuang,WANG Fan. Relationship between PDE4C gene methylation in peripheral blood leukocytes,interaction of environmental factors and pathogenesis of breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 233-238.
[3]	CHEN Yanbo, KONG Dejia, ZHANG Jinfeng, MA Zhigang. Correlation between CYP2D6 gene polymorphism and tamoxifen metabolism in breast cancer patients [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 110-114.
[4]	SUN Jianghong, HAO Mingzhu, JIANG Dan, GUO Fei, LI Xiaomei. FFDM differential diagnosis of mastitis,benign hyperplasia and breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 139-141.
[5]	MA Zhijie, WANG Fan, ZHAO Yashuang. Analysis of life quality and influencing factors in breast cancer patients with chemotherapy [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 149-154.
[6]	MA Zhingying, SHANG Naijian, CAI Miaotian, SHEN Yang, JIANG Zhiyun. Correlation between HER-2 receptor of progesterone and estrogen receptor-positive breast cancer and mammography imaging & clinicopathological features [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 47-51.
[7]	LIN Rongjie, YIN Hang, ZHOU Yunfeng. Effect of ON123300 on ER+ human breast cancer MCF-7 cells and its mechanism [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 193-197.
[8]	LI Lin, LI Zhigao. The relationship between metformin and different molecular subtypes of breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 267-270.
[9]	ZHENG Wei, XU Shouping, PANG Da. Expression,prognosis and function of long chain non-coding RNA-Linc00152 in breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 7-13.
[10]	YIN Yulian, ZHANG Weihong, ZHOU Yue, YE Meina, CHEN Hongfeng. Correlation between single nucleotide polymorphisms of ERα gene and bone loss associated with aromatase inhibitors in postmenopausal women with breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 14-18.
[11]	LI Yujiao, SHANG Naijian. Research progress of imaging evaluation of neoadjuvant chemotherapy in breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 63-67.
[12]	WANG Jiana, SHEN Jianjun, ZHANG Yanhong, WANG Jiatian, LI Wenxiu, PAN Junying. Expression of Ki-67 and PTEN in oral adenoid cystic carcinoma and its clinical significance [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(6): 489-493.
[13]	CHEN Zhuo, KONG Yiran. Effect of silencing UHRF1 on proliferation and metastasis of breast cancer cells [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(6): 512-518.
[14]	LI Hongyang, SUN Liang, JIANG Xing, YUAN Guangjun, LIU Yan. Dauricine enhances the sensitivity of 5-fluorouracil in human breast cancer MCF-7 cells [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(5): 385-389.
[15]	ZHANG Yunyan, LIU Yaqin, WANG Lei, ZHANG Lin, CHENG Haiyan, YANG Shanshan. Relationship between expression of RIZ1 and clinicopathological factors or radiosensitivity in human cervical squamous cell carcinoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(5): 405-410.

The expression of HLA-G in breast cancer and its significance

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments