FBXW10与Cyclin E在肾透明细胞癌中的表达及临床意义

doi:10.11904/j.issn.1002-3070.2019.04.007

Abstract

Abstract: Objective The aim of this study was to investigate the expressions of and clinical significance of F-box/WD-40 domain protein 10(FBXW10)as well as the expression of cell cycle protein cyclin E(cyclin E)in renal clear cell carcinoma.Methods Immunohistochemistry SP method was used to detect the expressions of FBXW10 and cyclin E protein in 60 cases of renal clear cell carcinoma and 20 cases of adjacent normal tissues.The relationship between the expressions of FBXW10 and cyclin E,and the clinical pathological characteristics was analyzed.Results The expression rates of FBXW10 and cyclin E protein in renal clear cell carcinoma were 40.0%,70.0%,respectively and adjacent normal tissues were 55.0% and 25.0%(P＜0.05).The expression of FBXW10 was correlated with the histologic grade of renal clear cell carcinoma(P=0.041),histologic grade(P=0.030);the expression of cyclin E was correlated with the pathological tumor stage of clear cell renal cell carcinoma(P=0.005),degree of differentiation(P=0.035),and distant metastasis(P=0.011).There was a significant correlation between the expressions of FBXW10 and cyclin E in renal clear cell carcinoma(r=0.533,P＜0.001).Conclusion FBXW10 and cyclin E may play important roles in the development of renal clear cell carcinoma.

Key words: Renal clear cell carcinoma, FBXW10, Cyclin E, Immunohistochemistry

CLC Number:

R737.1

WANG Jinyou, HE Ke, XIE Dongdong, BI Liangkuan, XU Dexiang, YU Dexin. Expression and significance of FBXW10 and cyclin E in renal clear cell carcinoma[J]. Journal of Practical Oncology, 2019, 33(4): 323-327.

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Expression and significance of FBXW10 and cyclin E in renal clear cell carcinoma

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