上皮性卵巢肿瘤组织中PSMD10、Ki67的表达及其临床病理意义

doi:10.11904/j.issn.1002-3070.2017.02.004

Abstract

Abstract: Objective The objective of this study was to investigate the expression of PSMD10 and Ki67 in epithelial ovarian tumors and its clinicopathological significance.Methods Immunohistochemical method was used to detect the expression of PSMD10 and Ki67 in 21 cases of ovarian benign tumor,31 cases of ovarian borderline tumor and 156 cases of ovarian cancer.Results The positive expression rate of PSMD10 and Ki67 in ovarian cancer was significantly higher than those of ovarian borderline and benign tumor(P＜0.05).The positive expression rate of PSMD10 in ovarian cancer tissues was not different from others groups(P＞0.05).There was significant different the positive expression rate of PSMD10 from clinical stage,pathological grade and residual tumor diameter(P＜0.05).There was a positive correlation between the expression of PSMD10 and Ki67 in ovarian cancer(P＜0.01).Conclusion PSMD10 and Ki67 play an important synergistic role in the carcinogenesis and progression of epithelial ovarian cancer.It can be used as an important index to judge the degree of malignancy and progression of ovarian cancer.Joint testing PSMD10 and Ki67 are used to guide the clinical diagnosis.

Key words: Ovarian cancer, PSMD10, Ki67, Immunohistochemistry

CLC Number:

R737.31

YU Ge,SUN Jianing,FENG Xiaoling. Expression of PSMD10 and Ki67 in epithelial ovarian carcinoma and its clinicopathological significance[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(2): 112-116.

References

1 Saini U,Naidu S,ElNaggar AC,et al.Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis:a potential therapeutic target[J].Oncogene,2016,197(10):1038-1047.
2 Zhang LL,Xu YL,Tang ZH,et al.Effects of alisol B 23-acetate on ovarian cancer cells:G1 phase cell cycle arrest,apoptosis,migration and invasion inhibition[J].Phytomedicine,2016,23(8):800-809.
3 Nishida N,Murakami F,Higaki K.Detection of serous precursor lesions in resected fallopian tubes from patients with benign diseases and a relatively low risk for ovarian cancer[J].Pathol Int,2016,66(6):337-342.
4 Zeggai S,Harir N,Tou A,et al.Immunohistochemistry and scoring of Ki-67 proliferative index and p53 expression in gastric B cell lymphoma from Northern African population:a pilot study[J].Gastrointest Oncol,2016,7(3):462-468.
5 Dmitrenko AP.Lateral differences in Ki-67 in breast cancer[J].Mol Clin Oncol,2016,4(6):1041-1044.
6 Alves AV,Ribeiro DR,Lima SO,et al.Expression of Ki-67 and P16 INK4a in chemically-induced perioral squamous cell carcinomas in mice[J].Rev Col Bras Cir,2016,43(2):72-79.
7 Himani B,Meera S,Abhimanyu S,et al.Ki-67 immunostaining and its correlation with microvessel density in patients with mutiple myeloma[J].Asian Pac J Cancer Prev,2016,17(5):2559-2564.
8 Soleimani M,Mirmohammad-Sadeghi H,Sadeghi-Aliabadi H,et al.Expression and purification of toxic anti-breast cancer p28-NRC chimeric protein[J].Adv Biomed Res,2016,19(5):70-88.
9 Lulla RR,Goldman S,Yamada T,et al.Phase 1 trial of p28(NSC745104),a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in pediatric patients with recurrent or progressive central nervous system tumors:A Pediatric Brain Tumor Consortium Study[J].Neuro Oncol,2016,18(8):1319-1325.
10 Uddin MH,Choi MH,Kim WH,et al.Involvement of PSMD10,CDK4,and tumor suppressors in development of intrahepatic cholangiocarcinoma of syrian golden hamsters induced by clonorchis sinensis and n-nitrosodimethylamine[J].PLoS Negl Trop Dis,2015,9(8):e0004008.
11 Chen BF,Suen YK,Gu S,et al.A miR-199a/miR-214 self-regulatory network via PSMD10,TP53 and DNMT1 in testicular germ cell tumor[J].Sci Rep,2014,18(4):6413-6420.
12 Siegel RL,Miller KD,Jemal A.Cancer statistics,2015[J].CA Cancer J Clin,2015,65(1):5-29.
13 Kurman RJ,Shih M.The origin and pathogenesis of epithelial ovarian cancer:a proposed unifying theory[J].Am J Surg Pathol,2010,34(3):433-443.
14 Cooke SL,Brenton JD.Evolution of platinum resistance in high-grade serous ovarian cancer[J].Lancet Oncol,2011,12(12):1169-1174.
15 Li J,Tian F,Li D,et al.MiR-605 represses PSMD10/Gankyrin and inhibits intrahepatic cholangiocarcinoma cell progression[J].FEBS Lett,2014,588(18):3491-3500.
16 Higashitsuji H,Itoh K,Nagao T,et al.Reduced stability of retinoblastoma protein by gankyrin,an oncogenic ankyrin-repeat protein overexpressed in hepatomas[J].Nature Medicine,2000,6(1):96-99.
17 Higashitsuji H,Itoh K,Sakurai T,et al.The oncoprotein gankyrin binds to MDM2/HDM2,enhancing ubiquitylation and degradation of p53[J].Cancer Cell,2005,8(1):75-87.
18 Man JH,Liang B,Gu YX,et al.Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells[J].The Journal of Clinical Investigation,2010,120(8):2829-2841.
19 Zhang J,Yang Y,Zhang Z,et al.Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway[J].Cancer Letters,2013,339(2):279-287.

[1]	LV Bowen, QIAN Jun, WANG Jie, QIAN Jingrong, LU Yingying, SU Liju, YANG Tongshu, LI Wenhui. Expression of MiR-455-5p in epithelial ovarian cancer and its target gene function [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 115-121.
[2]	SONG Ling, FU Qiong. Study of the effect of astragalin on proliferation of ovarian cancer cells by inhibiting the glycolytic pathway induced Via HIF-1α [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 503-509.
[3]	HE Xu, YE shangmian, DONG dandan, LI Ke. The expression of HLA-G in breast cancer and its significance [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 410-414.
[4]	JIANG Liangliang, WANG Jing. Progress in diagnosis and treatment of distant metastasis of epithelial ovarian cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 480-482.
[5]	LIANG Guanying,CHI Qiujun,LI Xiaomei. Effect and mechanism of Vorinostat on the proliferation and apoptosis of ovarian cancer SKOV3 cells [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(4): 298-302.
[6]	LI Wenhui, LV Bowen, QIAN Jun, SU Liju, YANG Tongshu, QIAN Jingrong, WANG Jie. Effect of microRNA-150 on proliferation,apoptosis,invasion and metastasis of epithelial ovarian cancer cells [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 208-213.
[7]	BI Qiling, ZHOU Lihong, HAN Yimin. Research progress of HOX gene and gynecologic tumor [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(2): 140-143.
[8]	WANG Jiana, SHEN Jianjun, ZHANG Yanhong, WANG Jiatian, LI Wenxiu, PAN Junying. Expression of Ki-67 and PTEN in oral adenoid cystic carcinoma and its clinical significance [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(6): 489-493.
[9]	LIU Xin, XU Yingjuan, YANG Chang, LOU Ge. Research progress on cadherins and integrins in ovarian epithelial cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(6): 548-553.
[10]	ZHANG Yunyan, LIU Yaqin, WANG Lei, ZHANG Lin, CHENG Haiyan, YANG Shanshan. Relationship between expression of RIZ1 and clinicopathological factors or radiosensitivity in human cervical squamous cell carcinoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(5): 405-410.
[11]	CHAI Jingbo, LI Ping, PEI Zhiping. The effects and mechanism of Lycopene on immune function of ovarian cancer rats [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 13-17.
[12]	MAO Wei, CHEN Qingjuan, SI Xiaomin, ZHANG Xiao, JIANG Cheng. Alpha-fetoprotein-high-producing hepatoid adenocarcinoma of the stomach:A case report and literature review [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 39-42.
[13]	SHI Qingyu,LI Liancai,MAI Wei,BAO Junjie,SONG Chunyu,QU Guofan. The study on SIRT4 gene expression and prognostic factors in osteosarcoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 502-506.
[14]	MAO Gaocai,ZHU Qicong,SHEN Hongfeng,TU Ruisha,YAN Qingguo. The clinicopathology analysis of three cases of carcinoma with multi-directional differentiation derived from junction of bladder and prostate [J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 538-542.
[15]	YU Dongyang,LIU Ziliang,HAN Lirong. The clinical features,curative effect and prognosis factors analysis in 58 patients with advanced ovarian cancer after intraperitoneal metastases [J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(4): 321-326.

Expression of PSMD10 and Ki67 in epithelial ovarian carcinoma and its clinicopathological significance

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments