SIRT4基因表达与骨肉瘤预后因素相关性研究

doi:10.11904/j.issn.1002-3070.2016.06.005

Abstract

Abstract: Objective To explore SIRT4 gene expression in tumor tissue and investigate the clinicolpathological features in osteosarcoma.Methods In this study,SIRT4 protein expression was detected in 106 osteosarcoma tissues and 36 paired neighboring non-tumorous tissues by immunohistochemistry and determined the correlation between the SIRT4 expression and the clinicopathological features.Results SIRT4 protein was dramatically decreased in osteosarcoma cells compared with neighboring non-tumorous bone cells.The low expression of SIRT4 was notably associated with a poor overall survival and disease-free survival in osteosarcoma patients.By using univariate and multivariate analyses,we confirmed that the increased SIRT4 expression was an independent factor in predicting better prognosis for patients.Conclusion SIRT4 expression might be an independent biomarker for prognostic evaluation of osteosarcoma.

Key words: Osteosarcoma, Immunohistochemistry, SIRT4 protein, Survival analysis

CLC Number:

R73-3

SHI Qingyu,LI Liancai,MAI Wei,BAO Junjie,SONG Chunyu,QU Guofan. The study on SIRT4 gene expression and prognostic factors in osteosarcoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 502-506.

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The study on SIRT4 gene expression and prognostic factors in osteosarcoma

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