长链非编码RNA在骨肉瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2019.03.014

Abstract

Abstract: Osteosarcoma(OS)is a malignant tumor that occurs mostly in children and adolescents with a poor prognosis.The 5-year survival rate and the survival rate of patients with lung metastasis or distant metastasis are still unsatisfactory.Currently,the treatment of osteosarcoma is still unsatisfactory under the bottleneck period.Long-chain non-coding RNA(LncRNA)is a non-protein-encoding RNA molecule involved in a variety of processes including gene expression,chromatin remodeling,post-transcriptional processing and transcription.LncRNAs are abnormally expressed in human cancers and they are involved in tumor development,progression and metastasis.This article reviews the research progress of long-chain non-coding RNA in osteosarcoma,which is intended to provide further research for osteosarcoma and propose new diagnosis and treatment strategies.

Key words: Osteosarcoma, Long-chain non-coding RNA, Tumor

CLC Number:

R738.1

LIU Yishu,QU Guofan. Progress in long-chain non-coding RNA in osteosarcoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 266-270.

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Progress in long-chain non-coding RNA in osteosarcoma

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