信号通路相关的microRNA在骨肉瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2019.06.013

Abstract

Abstract: Osteosarcoma is a relatively common malignant tumor originating from bone tissue,which occurs in children and adolescents.In recent years,the role of microRNA in the development of bone tumors has become a hot topic.Numerous studies have shown that microRNA can affect the expression of target genes through MAPK/ERK,PI3K/AKT,Wnt/β-catenin and other signaling pathways,thereby regulating the biological functions such as proliferation,differentiation and invasion of tumor cells,and the development of osteosarcoma.MicroRNA is closely related to the development,clinical treatment and prognosis of osteosarcoma.

Key words: MicroRNA, Osteosarcoma, Treatment, Signaling pathway

CLC Number:

R738.1

CAO Shu, LI Shasha, YANG Dan. Advances in research of signaling pathway-related microRNA in osteosarcoma[J]. Journal of Practical Oncology, 2019, 33(6): 544-548.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2019.06.013

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2019/V33/I6/544

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Advances in research of signaling pathway-related microRNA in osteosarcoma

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