Agrin参与恶性肿瘤发生发展的研究现状

doi:10.11904/j.issn.1002-3070.2023.06.009

Abstract

Abstract: Malignant tumor has become the largest disease threatening human health.The global incidence of cancer is increasing year by year.At present,the poor quality of life and drug resistance of patients with advanced and recurrent cancer are becoming increasingly obvious.Reducing the invasion and metastasis of tumor,improving the survival and prognosis of tumor patients,are urgent problems to be solved in tumor treatment.Agrin is a membrane protein associated with synaptic formation,and recent studies have shown that Agrin plays an important role in the occurrence and development of tumors.Agrin is expressed in malignant tumors and immune cells,playing an important regulatory role in tumor angiogenesis,cell proliferation and migration,chemotherapy resistance,and neutrophil infiltration.This article summarizes and analyzes the current research status of Agrin,especially its related role and mechanism in the occurrence and development of malignant tumors.

Key words: Agrin, Malignant tumor, Signaling pathway

CLC Number:

R730.2

ZHAO Shibo, CHEN Yongfeng, LI Huiyi, FU Aizhen. Research status of Agrin involvement in the occurrence and development of malignant tumors[J]. Journal of Practical Oncology, 2023, 37(6): 507-512.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2023.06.009

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2023/V37/I6/507

References

1 Tian C,Öhlund D,Rickelt S,et al.Cancer cell-derived matrisome proteins promote metastasis in pancreatic ductal adenocarcinoma[J].Cancer Res,2020,80(7):1461-1474.
2 Yan M,Xing GL,Xiong WC,et al.Agrin and LRP4 antibodies as new biomarkers of myasthenia gravis[J].Ann N Y Acad Sci,2018,1413(1):126-135.
3 Kim JH,Ko IK,Jeon MJ,et al.Pelvic floor muscle function recovery using biofabricated tissue constructs with neuromuscular junctions[J].Acta Biomater,2021,121:237-249.
4 Belotti E,Schaeffer L.Regulation of gene expression at the neuromuscular Junction[J].Neurosci Lett,2020,735:135163.
5 Lv R,Duan L,Gao J,et al.Bioinformatics-based analysis of the roles of basement membrane-related gene AGRN in systemic lupus erythematosus and pan-cancer development[J].Front Immunol,2023,14:1231611.
6 Baehr A,Umansky KB,Bassat E,et al.Agrin promotes coordinated therapeutic processes leading to improved cardiac repair in pigs[J].Circulation,2020,142(9):868-881.
7 Njah K,Chakraborty S,Qiu B,et al.A role of agrin in maintaining the stability of vascular endothelial growth factor receptor-2 during tumor angiogenesis.Cell Rep,2019,28(4):949–965.
8 Lv X,Fang C,Yin R,et al.Agrin para-secreted by PDGF-activated human hepatic stellate cells promotes hepatocarcinogenesis in vitro and in vivo[J].Oncotarget,2017,8(62):105340-105355.
9 Zhang H,Liang J,Lu T,et al.AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target[J].Pharmacol Res,2023,194:106819.
10 Rivera C,Zandonadi FS,Sánchez-Romero C,et al.Agrin has a pathological role in the progression of oral cancer[J].Br J Cancer,2018,118(12):1628-1638.
11 冯思佳.Agrin在人乳头瘤病毒相关宫颈癌细胞中的作用[D].新乡医学院,2016.
12 Chakraborty S,Njah K,Hong W.Agrin mediates angiogenesis in the tumor microenvironment[J].Trends Cancer.2020,6(2):81-85.
13 Ye P,Fu Z,Chung JY,et al.Endothelial agrin is dispensable for normal and tumor angiogenesis.Front Cardiovasc Med[J].Front Cardiovasc Med,2022,8:810477.
14 Brabletz T,Kalluri R,Nieto MA,et al.EMT in cancer[J].Nat Rev Cancer,2018,18(2):128-134.
15 Tian C,Clauser KR,Öhlund D,et al.Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells[J].Proc Natl Acad Sci U S A,2019,116(39):19609-19618.
16 冯思佳,崔静,杨璐.集聚蛋白基因在不同宫颈癌细胞中的表达[J].新乡医学院学报,2016,05:365-368.
17 Makovec T.Cisplatin and beyond:molecular mechanisms of action and drug resistance development in cancer chemotherapy[J].Radiol Oncol,2019,53(2):148-158.
18 Lazaridis K,Tzartos SJ.Myasthenia gravis:autoantibody specificities and their role in MG management[J].Front Neurol,2020,11:596981.
19 Masucci MT,Minopoli M,Carriero MV.Tumor associated neutrophils.their role in tumorigenesis,metastasis,prognosis and therapy[J].Front Oncol,2019,9:1146.
20 Galdiero MR,Varricchi G,Loffredo S,et al.Potential involvement of neutrophils in human thyroid cancer[J].PLoS One,2018,13(6):e0199740.
21 Adamiok-Ostrowska A,Grzanka M,Czarnocka B.Agrin is a novel oncogenic protein in thyroid cancer[J].Oncol Lett,2023,26(5):1-8.
22 He M,Cheng C,Tu J,et al.Agrin expression is correlated with tumor development and poor prognosis in cholangiocarcinoma[J].J Int Med Res,2021,49(5):3000605211009722.
23 Chakraborty S,Hong W.Linking extracellular matrix agrin to the hippo pathway in liver cancer and beyond[J].Cancers(Basel),2018,10(2):45-45.
24 Wang ZQ,Sun XL,Wang YL,et al.Agrin promotes the proliferation,invasion and migration of rectal cancer cells via the WNT signaling pathway to contribute to rectal cancer progression[J].J Recept Signal Transduct Res,2021,41(4):363-370.
25 Han L,Shi H,Ma S,et al.Agrin promotes non-small cell lung cancer progression and stimulates regulatory T cells via increasing IL-6 secretion through PI3K/AKT pathway[J].Front Oncol,2022,11:804418.
26 Fu JW,Kong Y,Sun X.Long noncoding RNA NEAT1 is an unfavorable prognostic factor and regulates migration and invasion in gastric cancer[J].J Cancer Res Clin Oncol,2016,142(7):1571-1579.
27 Peng W,Wang Z,Fan H.LncRNA NEAT1 impacts cell proliferation and apoptosis of colorectal cancer via regulation of Akt signaling[J].Pathol Oncol Res,2017,23(3):651-656.
28 Zhang H,Liang J,Lu T,et al.AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target[J].Pharmacol Res,2023,194:106819.
29 Liu Y,Fang B,Feng X,et al.Mechanism of IDH1-R132H mutation in T cell acute lymphoblastic leukemia mouse model via the Notch1 pathway[J].Tissue Cell,2022,74:10167-10174.
30 Wang W,Sun R,Zeng L,et al.GALNT2 promotes cell proliferation,migration,and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma[J].Life Sci,2021,276:119439.
31 Zhang G,Tanaka S,Jiapaer S,et al.RBPJ contributes to the malignancy of glioblastoma and induction of proneural-mesenchymal transition via IL-6-STAT3 pathway[J].Cancer Sci,2020,111(11):4166-4176.
32 Nukaga S,Yasuda H,Tsuchihara K,et al.Amplification of EGFR wild-type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors[J].Cancer Res,2017,77(8):2078–2089.
33 Jiang W,Xu Z,Yu L,et al.MicroRNA-144-3p uppressed TGF-Beta1-induced lung cancer cell invasion and adhesion by regulating the Src-Akt-Erk Pathway[J].Cell Biol Int,2019,44(1):51–61.
34 Chen L,Wu Q,Xu X,et al.Cancer/testis antigen LDHC promotes proliferation and metastasis by activating the PI3K/Akt/GSK-3β-signaling pathway and the in lung adenocarcinoma[J].Exp Cell Res,2021,398(2):112414.
35 Jiang H,Zhou Z,Jin S,et al.PRMT9 promotes hepatocellular carcinoma invasion and metastasis via activating PI3K/Akt/GSK-3β/Snail signaling[J].Cancer Sci,2018,109(5):1414-1427.

[1]	XUE Yuting, MAO Xionghui, SUN Ji, YUAN Zhennan. The role of long-chain non-coding RNA LINC-PINT in drug sensitivity of hypoxia induced in head and neck squamous cell carcinoma through the Hippo/YAP signaling pathway [J]. Journal of Practical Oncology, 2023, 37(6): 466-471.
[2]	CHENG Jin, WANG Wei. Research progress on retinoic acid-induced proteins in malignant tumors of the digestive system [J]. Journal of Practical Oncology, 2023, 37(6): 502-506.
[3]	WEN Hongmei, CHEN Yang, SHI Qingping, ZHU Yunfang, REN Siying, TANG Xian, SHAO Ying, WU Fuxian, LI Yunfei. Analysis of incidence and mortality of malignant tumors in cancer registration areas of Yunnan province in 2018 [J]. Journal of Practical Oncology, 2023, 37(4): 293-300.
[4]	MING Cheng, WU Yun. Research progress of Wnt/β-catenin signaling pathway and its inhibitors in gastric cancer [J]. Journal of Practical Oncology, 2023, 37(2): 190-194.
[5]	YANG Jianhua, LUO Saimei, LONG Xintian, LI Wei, YANG Birong, YU Longtao, ZHANG Teng, WEN Hongmei. Analyses of incidence and mortality of malignant tumors in cancer registration areas of Yunnan province in 2017 [J]. Journal of Practical Oncology, 2023, 37(1): 6-10.
[6]	MA Jixiong, MA Juhong, ZHUO Hong, LU Zhaoxia, DING Gaoheng, LIU Yuqin. Incidence and mortality of malignant tumors of Baiyin in Gansu province,2018 [J]. Journal of Practical Oncology, 2023, 37(1): 11-16.
[7]	WANG Qin, LIU Junjie, LU Xiuxin, WU Yafei, ZHANG Wenhao. Research progress of nanocombination therapy based on ferroptosis in the treatment of malignant tumors [J]. Journal of Practical Oncology, 2022, 36(5): 429-434.
[8]	ZHAO Zinan, WANG Guonian. Research progress of SOX4 in digestive system malignant tumors [J]. Journal of Practical Oncology, 2022, 36(4): 364-368.
[9]	CHEN Han, LUO Xiaoyong, LI Chaoping, GUO Cairu, JU Wencui, ZHAI Yangyang, SHI Xinpeng. The effect of lncRNA CASC2 on the function and angiogenesis of colorectal cancer cells [J]. Journal of Practical Oncology, 2022, 36(2): 111-118.
[10]	WU Fangfang, ZHENG Tongsen. Research status and prospect of adjuvant therapy for biliary tract malignant tumors [J]. Journal of Practical Oncology, 2022, 36(2): 156-161.
[11]	TANG Ju, SHANG Lihua. The relationship between BMI and the efficacy of immune checkpoint inhibitors in the treatment of malignant tumors [J]. Journal of Practical Oncology, 2022, 36(2): 188-192.
[12]	WANG Yanping, QIU Lin, WU Meng, SA Rina. Analysis of the incidence and mortality of malignant tumors in Shaanxi province in 2016 [J]. Journal of Practical Oncology, 2022, 36(1): 1-6.
[13]	LI Na, DENG Qian, JIANG Jianjun. The role of NF-κB signaling pathway in chemotherapy resistance of malignant tumors [J]. Journal of Practical Oncology, 2021, 35(6): 580-584.
[14]	FU Yan¹, YAN Lili², WANG Chunyu², FU Fangmin², DONG Hua³. Analysis for the prevalence of malignant tumors in Qionghai city from 2010 to 2016 [J]. Journal of Practical Oncology, 2021, 35(5): 396-401.
[15]	JIN Shengye, PANG Da. Research progress in the mechanism of oncolytic virus inducing tumor apoptosis and activating anti-tumor immunity [J]. Journal of Practical Oncology, 2021, 35(5): 462-467.

Research status of Agrin involvement in the occurrence and development of malignant tumors

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments