Abstract: Objective The objective of this study was to analyze the epidemic characteristics and changing trends of thyroid cancer in cancer registration areas of Fujian province from 2011 to 2020, and provide a scientific basis for the prevention and control work. Methods The incidence and death cases were collected and organized in the cancer registration area of Fujian province from 2011 to 2020. The data were combined and analyzed in the registered areas that met the evaluation criteria. The crude incidence and mortality, age-standardized rate(ASR)China, ASR Word, cumulative rate(0-74 years old)and annual percentage change(APC)of thyroid cancer were calculated. The population standardization rate was calculated using the population structure of the 2000 National Population census and the Segi′s world population structure. Results The incidence of thyroid cancer from 2011 to 2020 was 18.48/100,000, the ASR China was 16.16/100,000, the ASR Word was 14.19/100,000, and the cumulative rate(0-74 years old)was 1.38%. The mortality of thyroid cancer was 0.79/100,000, the ASR China was 0.60 /100,000, the ASR Word was 0.59/100,000, and the cumulative rate(0-74 years old)was 0.07%. The incidence was at a low level in the age group of 0-20 years old, rising rapidly after 20 years old, and falling after reaching the highest level in the age group of 50-54 years old(38.67/100,000). The mortality of thyroid cancer was at a low level before the age of 40, but significantly increases after the age of 40, reaching its highest level in the age group over 85(5.79/100,000). The APC values of total incidence, male incidence, female incidence, urban incidence, and rural incidence of thyroid cancer from 2011 to 2020 in Fujian province were 23.32%,25.69%,22.44%,30.05%,16.60%, respectively, the APC of age-standardized rate were 23.15%,25.96%,22.01%,30.82%, and 14.85%, respectively, showing an upward trend(P＜0.05). The APC values of total mortality, urban mortality and rural mortality were 6.89%,8.10% and 5.67%, respectively, showing an upward trend(P＜0.05), while age-standardized mortality, male and female crude mortality and China age-standardized mortality, and the age-standardized mortality in urban and rural areas were relatively stable. Conclusion Thyroid cancer is one of the main malignant tumors in Fujian province, with gender and urban-rural differences in epidemic characteristics. The incidence trend is obvious, and targeted comprehensive prevention and treatment work should be carried out.

Key words: Thyroid cancer, Incidence, Mortality, Changing trend, Cancer registration, Fujian