Abstract: To explore the clinical,pathological and immunohistochemical features of carcinoma with multi-directional differentiation derived from junction of bladder and prostate.We collected clinical data and tissue samples of three typical cases of carcinoma from our hospital.Routine preparation of slides and immunohistochemical methods combined with clinical data and pathological changes analysis were adopted.We found that all 3 cases occurred in the elderly lesions involving the bladder and prostate.Dysuria was the main common symptom.All the cases had a history of chronic inflammation in urethral and prostate gland.The following up data showed that survival time in two of them were no more than 15 months.The third patient without chemotherapy who took drugs of bicalutamide,enantone and pamidronate still was alive after 28 months.The pathological changes of these cases had the common features with diversity.They all showed the structure with nests,papillary,solid,adenoid,single or syncytial cells.The nuclear of cancer cell was enlarged with hyperchromatic feature.The mitotic figures were easily found.The metaplasia and atypical hyperplasia of prostate were all found.The immunohistochemistry results showed positive results for HCK,LCK,p53,p63,PSA,P504S and negative for vimentin and S-100.The average proliferation index of Ki-67 was 77%.

Key words: Prostate cancer, Urothelial carcinoma, Multi-directional differentiation, Immunohistochemistry