Aurora-A参与非小细胞肺癌化疗药耐药与患者预后的关系

doi:10.11904/j.issn.1002-3070.2016.02.001

Abstract

Abstract: Objective To identify the expression of Aurora-A and its correlation with cisplatin resistance and prognosis in non-small cell lung cancer(NSCLC).Methods A total of 62 NSCLC patients treated by surgery and adjuvant cisplatin-based chemotherapy were included in our study.The expression of Aurora-A was determined by immunohistochemical(IHC)analysis.Correlation between Aurora-A expression and clinic pathological variables was estimated.The prognostic significances were assessed by Kaplan-Meier method,and the differences in survival probabilities were evaluated by the Log-rank test.Results IHC showed that 26 out of the 62 NSCLC patients were with high Aurora-A.There was no significant association between Aurora-A expression and clinic pathological variables.The overall survival of patients with high Aurora-A expression(median survival time:50.1 months)was significantly poorer than those with low Aurora-A expression(median survival time:55.8 months).Conclusion The present study suggests that high Aurora-A expression is correlated with cisplatin-based chemotherapeutic resistance and predicts poor patient survival in NSCLC.However,further in vitro study is needed.

Key words: Aurora-A, Non-small cell lung cancer, Prognosis

CLC Number:

R734.2

YE Leiguang, YAN An, LIU Baogang. Relationship between Aurora-A mediated drug resistance and prognosis of patients with non-small cell lung cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(2): 97-102.

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Relationship between Aurora-A mediated drug resistance and prognosis of patients with non-small cell lung cancer

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