老年小细胞肺癌的治疗

doi:10.11904/j.issn.1002-3070.2016.05.016

Abstract

Abstract: Recently,the incidence rate of small cell lung cancer in elderly patients has been increasing.The mainly therapeutic approach of small cell lung cancer consists of radiotherapy,chemotherapy and surgery,with the treatment purpose of prolonging survival time and improving life quality.As the huge development of accurate radiotherapy technology occurred in the past a few years,radiotherapy could play more and more important roles in the treatment with elderly patients.Yet,there is no unified standards of treatment for small cell lung cancer in elderly patients.Therefore,we give a review on the latest processes and research on the treatment of small cells lung cancer in elderly patients.

Key words: Aged, Small cell lung Cancer, Therapy

CLC Number:

R734.2

XIAO Yao, XU Xiangying, HU Songliu. Treatment of small cell lung cancer in elderly patients[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 463-467.

References

1 http://seer.cancer.gov/statfacts/html/lungb.html,2015-11-18/2016-04-10.
2 Rossi A,Maione P,Colantuoni G,et al.Treatment of small cell lung cancer in the elderly[J].Oncologist,2005,10(6):399-411.
3 Takada M,Fukuoka M,Kawahara M,et al.Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer:results of the Japan Clinical Oncology Group Study 9104[J].J Clin Oncol,2002,20(14):3054-3060.
4 Fried DB,Morris DE,Poole C,et al.Systematic review evaluating the timing of thoracic radiation therapy in combined modality therapy for limited-stage small-cell lung cancer[J].J Clin Oncol,2004,22(23):4837-4845.
5 Turrisi AT,Kim K,Blum R,et al.Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide[J].N Engl J Med,1999,340(4):265-271.
6 Yuen AR,Zou G,Turrisi AT,et al.Similar outcome of elderly patients in intergroup trial 0096:Cisplatin,etoposide,and thoracic radiotherapy administered once or twice daily in limited stage small cell lung carcinoma[J].Cancer,2000,89(9):1953-1960.
7 Corso CD,Rutter CE,Park HS,et al.(S041)the role of chemoradiation in elderly limited-stage small-cell lung cancer patients[J].Oncology(Williston Park),2015,29(4 Suppl 1):1-2.
8 Corso CD,Rutter CE,Park HS,et al.Role of chemoradiotherapy in elderly patients with limited-stage small-cell lung cancer[J].J Clin Oncol,2015,33(36):4240-4246.
9 Su J,Zhu S,Liu Z,et al.A study of elderly patients with limited-stage small-cell lung cancer after combined chemoradiotherapy[J].Am J Ther,2012,21(5):371-376.
10 Shukuya T,Takahashi T,Harada H,et al.Chemoradiotherapy for limited-disease small-cell lung cancer in elderly patients aged 75 years or older[J].Jpn J Clin Oncol,2013,43(2):176-183.
11 Arriagada R,Le Chevalier T,Riviere A,et al.Patterns of failure after prophylactic cranial irradiation in small-cell lung cancer:analysis of 505 randomized patients[J].Ann Oncol,2002,13(5):748-754.
12 Auperin A,Arriagada R,Pignon JP,et al.Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission.Prophylactic Cranial Irradiation Overview Collaborative Group[J].N Engl J Med,1999,341(7):476-484.
13 Eaton BR,Kim S,Marcus DM,et al.Effect of prophylactic cranial irradiation on survival in elderly patients with limited-stage small cell lung cancer[J].Cancer,2013,119(21):3753-3760.
14 Jackman DM,Johnson BE.Small-cell lung cancer[J].Lancet,2005,366(9494):1385-1396.
15 Janssen-Heijnen ML,Maas HA,Koning CC,et al.Tolerance and benefits of treatment for elderly patients with limited small-cell lung cancer[J].J Geriatr Oncol,2014,5(1):71-77.
16 Caprario LC,Strauss GM.The benefit of chemotherapy in elderly patients with small cell lung cancer[J].Expert Rev Anticancer Ther,2014,14(6):645-647.
17 Fisher S,Al-Fayea TM,Winget M,et al.Uptake and tolerance of chemotherapy in elderly patients with small cell lung cancer and impact on survival[J].J Cancer Epidemiol,2012,2012:708936.
18 Quoix E,Breton JL,Daniel C,et al.etoposide phosphate with carboplatin in the treatment of elderly patients with small-cell lung cancer:a phase ii study[J].Ann Oncol,2001,12(7):957-962.
19 Kim E,Biswas T,Bakaki P,et al.Comparison of cisplatin/etoposide versus carboplatin/etoposide concurrent chemoradiation therapy for limited-stage small cell lung cancer(LS-SCLC)in the elderly population(age >65 years)using national SEER-Medicare data[J].Pract Radiat Oncol,2016,6(5):163-169.
20 Zhu H,Zhou Z,Xue Q,et al.Treatment modality selection and prognosis of early stage small cell lung cancer:retrospective analysis from a single cancer institute[J].Eur J Cancer Care(Engl),2013,22(6):789-796.
21 Jeremic B,Shibamoto Y,Nikolic N,et al.Role of radiation therapy in the combined-modality treatment of patients with extensive disease small-cell lung cancer:A randomized study[J].J Clin Oncol,1999,17(7):2092-2099.
22 Yee D,Butts C,Reiman A,et al.Clinical trial of post-chemotherapy consolidation thoracic radiotherapy for extensive-stage small cell lung cancer[J].Radiother Oncol,2012,102(2):234-238.
23 Palma DA,Warner A,Louie AV,et al.Thoracic radiotherapy for extensive stage small-cell lung cancer:a meta-analysis[J].Clin Lung Cancer,2015,17(4):239-244.
24 Wu D,Fang J,Nie J,et al.Effects of local radiation combined with chemotherapy in the treatment of patients with extensive-stage small cell lung cancer[J].Chin J Lung Cancer,2015,18(5):272-279.
25 Zhu H,Zhou Z,Wang Y,et al.Thoracic radiation therapy improves the overall survival of patients with extensive stage small cell lung cancer with distant metastasis[J].Cancer,2011,117(23):5423-5431.
26 Slotman BJ,Van Tinteren H,Praag JO,et al.Use of thoracic radiotherapy for extensive stage small-cell lung cancer:a phase 3 randomised controlled trial[J].Lancet,2015,385(9962):36-42.
27 Qin T,Zhou N,Zeng YD,et al.Benefit from thoracic radiotherapy in patients with extensive-disease small-cell lung cancer with elevated lactate dehydrogenase[J].Onco Targets Ther,2016,9:1095-1103.
28 Rodrigues G,Macbeth F,Burmeister B,et al.Consensus statement on palliative lung radiotherapy:third international consensus workshop on palliative radiotherapy and symptom control[J].Clin Lung Cancer,2012,13(1):1-5.
29 Kepka L,Olszyna-Serementa M.Palliative thoracic radiotherapy for lung cancer[J].Expert Rev Anticancer Ther,2010,10(4):559-569.
30 Rule WG,Foster NR,Meyers JP,et al.Prophylactic cranial irradiation in elderly patients with small cell lung cancer:findings from a North Central Cancer Treatment Group pooled analysis[J].J Geriatr Oncol,2015,6(2):119-126.
31 Niell HB,Herndon JE,Miller AA,et al.Randomized phase III intergroup trial of etoposide and cisplatin with or without paclitaxel and granulocyte colony-stimulating factor in patients with extensive-stage small-cell lung cancer:Cancer and Leukemia Group B Trial 9732[J].J Clin Oncol,2005,23(16):3752-3759.
32 Noda K,Nishiwaki Y,Kawahara M,et al.Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer[J].N Engl J Med,2002,346(2):85-91.
33 Okamoto H,Watanabe K,Kunikane H,et al.Randomised phase iii trial of carboplatin plus etoposide vs split doses of cisplatin plus etoposide in elderly or poor-risk patients with extensive disease small-cell lung cancer:jcog 9702[J].Br J Cancer,2007,97(2):162-169.
34 Kim YS,Park SH,Kyung SY,et al.Irinotecan plus carboplatin in patients with extensive-disease small-cell lung cancer[J].Med Oncol,2011,28(1):342-350.
35 Smit EF,Baas P.Lung cancer in 2015:Bypassing checkpoints,overcoming resistance,and honing in on new targets[J].Nat Rev Clin Oncol,2016,13(2):75-76.

[1]	LI Jiaqi,LUAN Jinwei,ZHANG Yu,LI Xianglan. Analysis of clinicopathological features,recurrence and metastasis in 763 triple-negative breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 244-249.
[2]	ZHU Lin,ZHANG Chunxia. Research progress of the nano drug-loading systems targeting tumor stem cells [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 276-279.
[3]	LI Shan,ZHAO Chunbo,QIAO Wenbo. Progress in the application of intraoperative radiotherapy in pancreatic cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 280-283.
[4]	FENG Yue,XING Linan,WANG Zhao,ZHANG Yunyan. Correlation between NLR and prognosis of concurrent chemoradiotherapy [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 284-288.
[5]	LIANG Hong, LI Qi, WANG Yaoxian, JIN Hong, WANG Tong, WANG Yanan, DUAN Yani, SONG Min. Interrupted time series trial for prevention of cardiovascular toxicity induced by chemotherapy in cervical cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 134-138.
[6]	MA Zhijie, WANG Fan, ZHAO Yashuang. Analysis of life quality and influencing factors in breast cancer patients with chemotherapy [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 149-154.
[7]	QIN Lanqun, ZOU Zhengyun. Progress in chemotherapy for malignant melanoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 167-172.
[8]	CHANG Xiaoxia, SONG Bingbing, LIU Jiaren. Research progress in phytochemicals for increasing sensitivity of tumor cells to chemotherapies [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 67-72.
[9]	DING Jiexian, ZHANG Jin, CHEN Yonggang, WANG Xingwen, WANG Shuanke. Progress in Wnt signaling pathway and tumorigenesis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 73-77.
[10]	ZHANG Pan, ZHANG Di, DAI Xiaobo. Advanced in re-radiotherapy for recurrent nasopharyngeal carcinoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 92-96.
[11]	LI Wanzhen, YIN Jun, LI Ping, LIN Xiaohui, ZHANG Guoqian, ZHANG Shuxu. The expression and role of miR-17 in radioresistant cells of non-small cell lung cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 391-397.
[12]	CAI Jing, HOU Yue. The expression and clinical significance of serum miR-195 in patients with non-small cell lung cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 415-419.
[13]	LI Yue, XU Ke, HAN Zengxiang, SUN Min, FAN Guohua, ZHANG Yong. Advances in the role of tumor-associated macrophage in colon cancer and targeted therapy [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 450-454.
[14]	JIANG Liangliang, WANG Jing. Progress in diagnosis and treatment of distant metastasis of epithelial ovarian cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 480-482.
[15]	CUI Xiaoyan,TU Qing,GAN Jianhui. Comparison between nalbuphine and oxycodone applied for patient controlled analgesia on postoperative immunological factor levels in patients with non-small cell lung cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(4): 309-314.

Treatment of small cell lung cancer in elderly patients

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments