Abstract: Breast paget's disease is a rare form of breast cancer,proposed by James Paget's in 1874.The pathogenesis of Paget's disease has been controversial;there are two main theories are epiphytic theory and transformation theory.In recent years,with the pathogenesis of breast Paget's disease development,some new hypotheses are input such as factor and receptor theory,endocrine theory and virus theory.Breast Paget's treatment methods= include improved radical surgery,simple breast resection,breast conserving surgery and other surgical treatment,according postoperative pathology combined with radiotherapy and chemotherapy.For those who have strong breast protection or plastic surgery will be given to patients with photodynamic therapy for neoadjuvant therapy.This paper reviews the relevant theories and hypotheses about the pathogenesis of mammary gland by collecting related literatures in recent years.

Key words: Breast paget's disease, Breast neoplasms, Pathogenesis, Treatment