Abstract: More and more evidence shows that uncontrollable inflammation has closely associated with tumorigenesis and development.Chronic inflammation may play a key role in various malignant tumors including bladder cancer.Bladder cancer is the most common malignant tumor of the urinary system.For non-muscle-invasive bladder cancer,the main method is still transurethral resection of bladder tumors,but its recurrence after surgery,the degree of malignancy after recurrence is gradually increased,so the need for postoperative adjuvant drug treatment reduces its recurrence and progression.Nowdays,immunotherapy has become a research hotspot and has achieved good effects.This article briefly describes the common chronic inflammation factors that induce bladder cancer and the related progression on immunotherapy.

Key words: Bladder cancer, Chronic inflammation, Inducing factors, Immunotherapy