Abstract: Objective The Objective of this study was to investigate effects of Leptin,vascular endothelial growth factor(VEGF)and different anesthetic Methods on prognosis of endometrial carcinoma(EC).Methods A retrospective analysis of 345 cases of endometrial medical records from January 2012 to November 2013 were performed.The patients were divided into normal endometrial group(63 cases),dysplasia group(85 cases)and EC group(197 cases).The EC group was classified according to the patient's voluntary choice of anesthesia:continuous epidural anesthesia + static inhalation combined general anesthesia(mode A)and static inhalation combined general anesthesia(mode B)as well as postoperative follow-up observed two kinds of anesthesia for prognosis impact of EC.Immunohistochemical SP method was used to detect the expression of Leptin and VEGF protein in different endometrial tissues.Kaplan-Meier single factor and Cox risk ratio model were used to analyze the effects of different anesthetic Methods and Leptin,VEGF protein on prognosis of EC patients.Results The positive expression rates of Leptin in normal endometrium,atypical hyperplasia and EC groups were 9.52%,32.94% and 78.68%,respectively,and the differences was statistically significant(χ²=105.873,P＜0.05).The positive expression rates of VEGF in normal endometrium,atypical hyperplasia and EC groups were 4.76%,21.18%,68.02%,respectively,and the differences was also statistically significant(χ²=98.976,P＜0.05).Kaplan-Meier univariate analysis showed that 1-,3-and 5-year survival rates of EC patients with anesthesia of model A were higher than those of model B(P＜0.05).The prognosis survival of mode A was significantly better than that of mode B.The survival rate of patients with positive expression of Leptin and VEGF were lower than that of patients with negative expression(P＜0.05).Cox model analysis of EC patients with prognosis showed that surgical pathological staging,histological grade,lymph node metastasis,and VEGF positive expression were significant factors affecting the EC prognosis.Conclusion The anesthesia method A is better than the method B in EC surgery,with good prognosis,long survival time and late metastasis.The expression of Leptin and VEGF in EC was significantly different from that in normal and dysplasia groups,and their expression in EC was positive synergistic.

Key words: Endometrial neoplasms, Anesthesia method, Leptin, VEGF protein, Prognosis