Abstract: Objective The aim of this study was to investigate the expression and clinical significance of TACC3 protein and p53 protein in primary liver cancer.Methods A total of 138 patients with primary liver cancer were enrolled in this study.The expression of TACC3 and p53 protein in normal tissues and primary liver cancer tissues were determined by enzyme-linked immunosorbent assay and immunohistochemistry.The relationships between the expression of TACC3 and p53 protein,and the clinicopathological parameters and prognosis were analyzed.Results The expression of TACC3 protein and p53 protein in primary liver cancer group was higher than those in the paracancerous group(P＜0.05).The positive rates of TACC3 and p53 in primary hepatocellular carcinoma group were higher than that in the paracancerous group(P＜0.05).The expression of TACC3 and p53 protein was not correlated with age(P＞0.05),but they were positively correlated with the TNM stage,pathological grade,recurrence,depth of invasion,lymphatic vascular infiltration,maximum diameter of tumor(≥5 cm)and lymph node metastasis(P＜0.01).The higher TNM stage,the pathological stage recurrence,deeper infiltration,lymphatic vascular infiltration,maximum tumor diameter ≥5 cm and lymph node metastasis,the higher TACC3 and p53 protein expression(P＜0.05).The 3-year survival rates in the negative expression TACC3 and p53 group were significantly higher than that in the positive expression of TACC3 and p53 positive groups(P＜0.01).Conclusion TACC3 and p53 proteins play an important role in the development of primary liver cancer.The expression of TACC3 and p53 protein in primary liver cancer tissues is increased.The low expression of TACC3 and p53 protein can significantly improve the prognosis of patients with primary liver cancer.

Key words: TACC3, p53, Primary hepatocellular carcinoma