Abstract: Retinoblastoma associated protein 48(RbAP48)is a new kind of tumor-specific protein belong to the WD-40 family of proteins.As a Rb-binding protein,it is the first identified peak protein isolated by different chromatin assembly,assembly and nucleosomal modification complexes(including histone acetylase HDACs),separating the first peak of identified proteins,in Rb/E2F transcription inhibition role in the signal transduction pathway.which is localized on E2F at the G1 phase and inhibits the transcription of this regulatory factor.At present,RbAP48 is abnormally expressed in malignant tumors such as lung cancer,cervical cancer,thyroid cancer,acute myeloid leukemia,breast cancer,gastric cancer and primary liver cancer,and it is closely related to the occurrence and development of tumors.Therefore,inorder to learn more about their interactions,RbAP48 is expressed in different kinds of tumors in the have important implications for understanding the occurrence of tumor development.

Key words: Retinoblastoma associated protein 48, E2F1, Histone deacetylase protein, Cell cycle, Rb pathway