Abstract: Objective The aim of this study was to investigate the effect of perioperative infection on cancer specific survival(CSS)after renal cell carcinoma resection.Methods A total of 1 800 patients with renal cell carcinoma from January 2006 to January 2013 in the Affiliated Hospital of Qingdao University were used as the research subjects,and the infection situation within 30 days after nephrectomy for renal cancer was analyzed.The CSS of infected and uninfected patients was analyzed by Kaplan-Meier curve,and Cox proportional hazard model was established to evaluate CSS.The factors such as sex,age,AJCC stage and classification,tumor size,pathological type,complications,surgical methods and systematic treatment were also controlled.Results The median age of 1 800 patients was 74 years(69~79 months),and the median follow-up time was 42 months(22~67 months).There were 141 cases of severe infection,296 cases of non-severe infection and 1 363 cases of non-infection.Kaplan-Meier analysis showed that severe infection had a tendency to improve CSS in patients with renal cancer(tumor diameter 7.0~9.9)(P=0.048),but severe infected patients with tumor diameter ≥10 cm or ＜7 cm had no effect on CSS(0.1~3.9 cm,P=0.120;4.0~6.9 cm,P=0.768;＞10 cm,P=0.412).Multivariate Cox regression analysis showed that severe infection could improve CSS in patients with renal cancer(HR=0.752,P=0.032).This effect was more obvious in patients with a tumor diameter(＞7 cm)(P=0.041),but it was not in patients with tumor diameter ＜ 7 cm(P=0.268).Conclusion Severe perioperative infection can improve CSS in patients with renal cancer with a tumor diameter of 7~10 cm,but it has no effect on CSS in patients with tumors ≥10 cm or ＜7 cm in diameter.

Key words: Infection, Renal cell carcinoma, Renal cancer resection, Tumor-specific survival rate