Journal of Practical Oncology ›› 2021, Vol. 35 ›› Issue (2): 184-187.doi: 10.11904/j.issn.1002-3070.2021.02.016

• Review • Previous Articles     Next Articles

Research progress of PARP inhibitors in the treatment of BRCA1/2 mutation metastatic breast cancer

HU Yang, ZHANG Qingyuan   

  1. Harbin Medical University Cancer Hospital,Harbin 150081,China
  • Received:2020-06-01 Revised:2020-08-06 Online:2021-04-28 Published:2021-04-27

Abstract: In recent years,PARP inhibitors have become a new hot spot in clinical research on the treatment of breast cancer.A large number of studies have confirmed that they are beneficial in patients with BRCA1/2 mutant metastatic breast cancer.This article reviews the mechanism of PARP inhibitors and the research progress of several PARP inhibitors in the treatment of patients with BRCA1/2 mutated metastatic breast cancer.

Key words: PARP inhibitors;BRCA1/2 mutation;Breast cancer;Treatment progress

CLC Number: