MT2-MMP在Ⅱ期肺腺癌中的表达及临床意义

doi:10.11904/j.issn.1002-3070.2021.03.009

Abstract

Abstract: Objective The aim of this study was to investigate the expression of MT2-MMP in lung adenocarcinoma and its clinical significance.Methods A total of 40 cases of lung adenocarcinoma with pathological TNM stage Ⅱ were collected,and the adjacent normal tissues were used as controls.Immunohistochemistry was used to detect the expression of MT2-MMP for semi-quantitative analysis.Chi-square test was used to analyze the relationship between MT2-MMP expression and clinicopathological characteristics.Combined with TCGA lung adenocarcinoma data,the expression of MT2-MMP was analyzed in lung adenocarcinoma.Results Lung adenocarcinoma tissues showed obvious pathological characteristics of disordered tumor proliferation.The expression of MT2-MMP in lung adenocarcinoma tissues was higher than that in adjacent normal tissues,and the difference was statistically significant(P＜0.001).The level of MT2-MMP in lung adenocarcinoma tissues was related to the tumor size of patients(P＜0.01),but was not significantly correlated with gender,age,presence or absence of lymphatic metastasis(P＞0.05).The TCGA data analysis results showed that the expression of MT2-MMP at the stage II of lung adenocarcinoma and other stages was significantly higher than that in normal tissues,and the difference was statistically significant(P＜0.01).Conclusion MT2-MMP is highly expressed at the stage II of lung adenocarcinoma,which may be involved in the early malignant progression of lung adenocarcinoma,and has potential value for the early diagnosis of lung adenocarcinoma.

Key words: Matrix metalloproteinase cell membrane anchoring type 2, Non-small cell lung cancer, Lung adenocarcinoma

CLC Number:

R734.2

WANG Junmei, PAN Huiqing, LI Jingyi, JIA Di, ZHAO Weiming, LV Changlian. The expression and clinical significance of MT2-MMP at the stage II of lung adenocarcinoma[J]. Journal of Practical Oncology, 2021, 35(3): 243-247.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.03.009

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I3/243

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The expression and clinical significance of MT2-MMP at the stage II of lung adenocarcinoma

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