Abstract: Objective To study the clinical characteristics,and the prognostic factors of triple negative breast cancer.Methods 130 triple negative breast cancer patients were reviewed on clinical characteristics and prognosis.All cases were lack of expression of estrogen receptor,progesterone receptor,and Her-2/neu determined by immunohistochemistry.Results 17.1% of all breast cancer patients(774 cases)were triple negative breast cancer,and 68.9% of triple negative breast cancer patients(91 cases)were premenopausal.53.8% of patients(71cases)had the tumors with T2 size,and 39.4% of them(52 patients)had lymph node metastasis.The rate of relapse in patients with lymph node metastasis was obviously higher than that in patients without lymph node metastasis(P=0.001).The median time of follow-up was 63 months.33 cases relapsed and 20 patients had died.23 patients had at least two organs metastasis.The 5-year disease-free and overall survival rates were 73.8% and 85.7%,respectively.Conclusion Triple negative breast cancer patients commonly have high rate of multiple distant metastasis in 2-3 years after treatment.The status of lymph node is the most important prognostic factor.The triple negative breast caner patients with lymph node metastasis have poor prognosis.