Abstract: Objective To investigste the correlation between the positive rate of HPV genetypes and the severity of cervical lesions.Methods Flow-through Hybridization was employed to detect the positive rate of high-risk HPV and the genetypes of HPV in cervical lesions.Results The positive rate of HPV test in cervicitis, CINI, CINII, CINIII and cervical cancer were 43.87%, 64.70%, 91.67%, 93.75% and 96% respectively.The most common genetypes in cervical lesions were HPV 16, 18, 52, 58, 33 and 31.The positive rate of multiplicitas genetypes infection in cervicitis, CINI, CINII, CINIII and cervical cancer were 35.8%, 45.9%, 54.9%, 60.8% and 70.2% respectively.Conclusions The positive rate increased with the process developing of cervical lesions.The most common genetypes in cervical lesions were HPV16, 18, 52, 58, 33 and 31.There were more multiplicitas genetypes with the development of cervical lesions.