Abstract: Objective This study focuses on different characteristics of different clinical subtypes breast cancer with local-regional recurrence after breast cancer operation,in order to give different treatments according to different clinical subtypes.Methods From 2007.1 to 2005.2,477 female patients with loco-regional recurrence of breast cancer in Tianjin cancer hospital were analyzed retrospectively,which was divided into luminal A type,luminal B type,HER-2(+)-type,basal-like type by immunohistochemical method.The subtypes were analyzed associated with local recurrence.Results In 477 cases of recurrence,recurrence rate within 1 year is 26.2%,recurrence rate within 2 years is 61.2%,recurrence rate after 2 years is 38.8%.In accordance with clinical types,luminal A type includes 63 cases,luminal B type includes 67 cases,HER-2(+)-type includes 110 cases,basal-like type includes 237cases,there is significantly difference among the 4 subtypes of recurrent rate within and after 2 years(P＜0.01).There are 310 cases metastasized after local recurrence,accounting for 65.0%.Metastasis rate after local recurrence is 28.6% in luminal A type,40.3% in luminal B type,60.9% in HER-2(+)type,83.5% in basal-like type.There is significantly difference of the metastasis rate after recurrence among the 4 subtypes clinical subtypes(P＜0.01).There is significantly difference in simple bone metastasis group(P＜0.01),There is no significantly difference among different groups of simple lung metastasis,liver metastasis and multiple-site metastasis(P＞0.05).Difference of disease progression time among different clinical subtypes is statistically significant(P＜0.05).5-year total survival rate after recurrence is 48.4%,5-year survival rate of luminal A type is 68.3%,luminal B type is 62.7%,HER-2(+)-type is 49.1%,basal-like type is 38.8%,There is significantly difference of the survival rate among different clinical subtypes(P＜0.01).Conclusion Among the recurrence cases,most of them happen in 2 years after breast cancer operation.Basal-like type breast cancer is the easiest one to relapse,which the metastasis rate after recurrence is the highest one,disease progression time is the shortest and survival rate is the lowest,HER-2(+)-type followed.Recurrence rate of luminal B type is lower,which the metastasis rate after recurrence is lower,disease progression time is longer and the survival rate is higher.Recurrence rate of luminal A type is the lowest one,which the metastasis rate after recurrence is the lowest one,disease progression time is the longest and the survival rate is the highest.Luminal B type is more likely to metastasize to the bone.