Abstract: Objective To evaluate the effect and toxicity of gemcitabine combined with oxaliplatin in the treatment of patients with relapsed or refractory of non-Hodgkin′s lymphoma.Methods twenty-eight patients with histologically confirmed relapsed or refractory non-Hodgkin′s lymphoma were enrolled in this study.The chemotherapy regimen consisted of gecitabine(1000mg/m² d1、8),oxaliplatin(130mg/m² d1)given every three weeks.Their clinical response was assessed after 2 cycles of chemotherapy.Results In the 28 patients,19 patients(67.8%)showed response including 8 patients complete response and 11 patients partial response.Nine patients′symptoms disappeared,and 4 in 13 patients were alleviated of type B symptoms.Drug related toxic effects was bone narrow depression.Conclusions GEMOX regimen possesses better short-term efficacy,acceptable toxicity.This protocol is worthy to warranted as salvage for relapsed or refractory non-Hodgkin′s lymphoma.