PRACTICAL ONCOLOGY JOURNAL ›› 2012, Vol. 26 ›› Issue (5): 418-422.doi: 10.3969/j.issn.1002-3070.2012.05.008

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Effects of As4S4 on the human ovarian cancer subcutaneously transplanted in nude mice

ZHANG Jiyan1,CHEN Jie1,GUO Xinggang2   

  1. 1.Department of Gynecology,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081,China;
    2.Department of Oncology,The Fouth Affiliated Hospital of Harbin Medical University,Harbin 150001
  • Received:2011-11-28 Online:2012-05-25 Published:2012-10-29

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Abstract: Objective To investigate the inhibitory effect of As4S4 on growth and apoptosis of the human ovarian cancer subcutaneously transplanted in nude mice.Methods We established the subcutaneously transplantated tumor of SKOV3 by BALB/C nude mice,and evaluated the inhibitory effect of As4S4 on the growth of tumor tissue;By RT-PCR,we evaluated the influence of As4S4 on the expression of Bcl-2/Bax mRNA in tumor tissue;By Westernblot,we evaluated the influence of As4S4on the expression of Bcl-2/Bax protein in tumor tissue.Results After subcutaneously transplanted tumor in nude mice,it was treated with different concentration of As4S4.It was significantly smaller in size and weight.The expression of Bcl-2 was down-regulated in As4S4 treated group,while Bax was up-regulated.Conclusion As4S4 suppresses the growth of implanted tumor in nude mice,and it induces tumor cells apoptosis.Anti-tumor activities of As4S4 might be related with inducing apoptosis and Bcl-2/Bax expression change.

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