Abstract: Objective To investigate long-term efficacy on the arterial chemotherapy and operation for invasive bladder cancer.Methods The 63 patients with invasive bladder cancer were divided into two groups were treated by partial cystectomy.30 patients among the total ones were arterial chemotherapy, they were treated with arterial chemotherapy on preoperative two weeks and postoperative two weeks.The other 33 patients in control group received no any arterial chemotherapy.All 63 cases were followed up five years after operation, in order to observe postoperative recurrence, the middle live time and compare survival rate between the two groups.Moreover, we observed the focus changes during the period of arterial chemotherapy and toxical-side effects about these drugs.Results The middle live time of arterial chemotherapy patients were 58 months, much longer than that of control group, the later was only 32 months.The survival rate in arterial chemotherapy group was higher than that in control group.Log-rank test was proved P＜0.01, which indicated significantly in statistics.We also found that the remission rate of the focus was 46.67 percent, the toxical-side effects were only 0-Ⅰdegree.Conclusions The recurrence rate could be obviously depressed and the survival rate could be increased in patients treated by partial cystectomy with invasive bladder cancer through preoperative and postoperative arterial chemotherapy, the part focus of infection could be relieved before operation.Furthermore, all cases could tolerate the toxical-side effects of the drugs.Therefore, arterial chemotherapy and operation for invasive bladder cancer is a potential way and deserves to spread clinically, especially with invasive bladder cancer.

Key words: Arterial Chemotherapy, Operation, Invasive Bladder Cancer, Curative Effect.