Journal of Practical Oncology ›› 2025, Vol. 39 ›› Issue (2): 73-79.doi: 10.11904/j.issn.1002-3070.2025.02.001

• Cancer Surveillance •     Next Articles

Analysis of leukemia disease burden in children and adolescents aged 0-19 years in China from 1990 to 2021

WANG Xinyu1, CAI Siyu2   

  1. 1. Big Data Center,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045, China;
    2. Center for Clinical Epidemiology and Evidence-based Medicine,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health
  • Received:2024-11-20 Revised:2025-02-03 Online:2025-04-28 Published:2025-05-06

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Abstract: Objective The Objective of this study was to analyze the disease burden trend of leukemia in children and adolescents aged 0-19 years in China from 1990 to 2021,and to provide a scientific evidence for the disease prevention and control strategy of this population. Methods The disease burden of leukemia in children and adolescents in China(excluding Taiwan)was analyzed using the Global Burden of Disease Database 2021(GBD 2021),including incidence,prevalence,mortality,and disability-adjusted life year(DALY).DALY consisted of two parts:years of life lost(YLL)and years lived with disability(YLD).The average annual percentage change(AAPC)was used to comprehensively evaluate the changing trends of various indicators from the disease burden of childhood leukemia in China from 1990 to 2021. Results In 2021,the age-standardized incidence,prevalence,mortality and DALY rates of the 0-19 years old population in China were 7.33/100,000,51.46/100,000,1.72/100,000,and 142.14/100,000,respectively.Among them,the age-standardized incidence,prevalence,mortality and DALY rates of males were higher than those of females.The incidence,prevalence,mortality and DALY rates of the 0- years old group were higher than those of other age groups.The age-standardized incidence,prevalence,mortality and DALY rates of acute lymphoblastic leukemia(ALL)were higher than those of other leukemia subtypes.From 1990 to 2021,the leukemia age-standardized incidence in the population aged 0 to 19 years did show a significant increase or decrease(AAPC=-0.32%,95% CI:-0.66%-0.02%);the age-standardized prevalence showed a significant increase(AAPC=3.05%,95% CI:2.68%-3.42%).While age-standardized mortality and DALY rates showed a downward trend(AAPC=-4.27%,95% CI:-4.53%-4.01%;AAPC=-4.3%,95% CI:-4.56%-4.05%). Conclusion From 1990 to 2021,the disease burden of leukemia in children and adolescents aged 0 to 19 years in China is increasing,the burden of death is decreasing,and the total DALY is decreasing.The burden of leukemia in this group varies greatly among different ages,genders,and leukemia subtypes.

Key words: Leukemia, Burden of diseases, Children, Adolescents

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