Abstract: Objective To investigate the expression of ERCC1 and β-Tubulin-?Ⅲ in ovarian epithelial carcinoma and their correlation with pathological characteristics as well as clinical significance, thus to provide theoretical basis for ovarian epithelial carcinoma individualized treatment. Methods The mRNA expressions of ERCC1 and TUBB3 in ovarian epithelial cancer tissues were detected by reverse transcription real-time fluorescence quantitative reactin (RTq-PCR).We analyzed the correlation of the expression of ERCC1 mRNA and TUBB3 mRNA and clinical pathological features of patients. Results ERCC1 and TUBB3 positively expressed in epithelial ovarian cancer. The rate of high expression of ERCC1 was 28.21%（22/78）and that of TUBB3 high expression was 29.49%（23/78）. By univariate analysis, high expression of ERCC1 mRNA and TUBB3 mRNA was only correlated with the size of residual mass（P＜0.05）, but not other clinical and pathological features. ERCC1 and TUBB3 expression was moderately correlated with each other（r=0.4249，P<0.05）. Conclusion ERCC1 and TUBB3 positively expresses in epithelial ovarian cancer and they are correlated with each other. High expression of ERCC1 mRNA and TUBB3 mRNA is positively correlated with the size of residual mass.

Key words: Epithelial ovarian carcinoma, ERCC1, TUBB3, RTq-PCR