PRACTICAL ONCOLOGY JOURNAL ›› 2011, Vol. 25 ›› Issue (5): 416-420.doi: 10.3969/j.issn.1002-3070.2011.05.004

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Clinical significance of Hepsin in epithelial ovarian carcinoma

LIU Junjun1,WANG Hongmei1,XIA Bairong3,LU Beiyan3,LOU Ge2   

  1. 1.Department of Pathology,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081;
    2.Department of Gynecogy,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081;
    3.Department of Obstetrics and Gynuology,First Affiliated Hospital of Jiamusi University,Jiamusi 154002
  • Received:2011-05-03 Online:2011-10-28 Published:2014-12-02

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Abstract: Objective To assess Hepsin expression in different ovarian tissues and in restigate the relationship between its expression and the clinical significance in epithelial ovarian cancer(EOC)patients.Methods Immunohistochemical staining was used to observe the expression of Hepsin in different ovarian tissues.The relationships of Hepsin expression,clinicopathological characteristics and responses to chemotherapy were also evaluated in ovarian cancer patients.Results We demonstrated that Hepsin expression levels were gradually elevated in normal tissues,borderline tissues and EOC tissues,respectively.Statistical analysis demonstrated that Hepsin expression status was positively correlated with the FIGO stage(P=0.0063),but negatively with histological differentiation(P＜0.001)in EOC patients.Conclusion It is suggested that Hepsin over-expression in ovarian carcinoma may be correlated with its progression.

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