Abstract: Objective To investigate the relationship between genotype of rs3803662 locus in TOX3 gene and clinical and pathological characteristics.Methods The TaqMan Single nucleotide polymorphism(SNP)assay was carried out to detect the dimorphism at the rs3803662 SNP loci.The distribution of genotype was compared in the different clinical characteristics and pathological characteristics.Results The distribution of rs3803662 genotype did not associate with pathological characteristics(P＞0.05),such as pathological type,histological grade,Lymph node involvement,ER status and etc.The proportion of variant genotype carriers was significantly higher in the IDC type and SBR3 grade than DCIS type and SBR2 grade,respectively(P＜0.05).The distribution of rs3803662 genotype was associated with age at diagnosis,clinical stages,menstrual duration and clinical characteristics(P＜0.05).The rate of homozygous mutation carrier increased significantly with the menstrual duration(P_Trend=0.034).Conclusion The variant genotype of rs3803662 in TOX3 was associated with DIC and SBR3.The distribution of rs3803662 genotype was associated with clinical stages,menstrual duration and clinical characteristics.